Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Atypical Pneumonia01:14

Atypical Pneumonia

Atypical pneumonia, often caused by Mycoplasma pneumoniae, is a form of pulmonary infection that differs from the classical presentation of bacterial pneumonia in both its cause and clinical symptoms. Mycoplasma pneumoniae is a pleomorphic bacterium notable for its lack of a rigid cell wall. This structural characteristic imparts resistance to beta-lactam antibiotics and significantly influences the bacterium’s behavior within the human host.Other pathogens responsible for the disease include...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...
Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Bacterial Phylum Spirochaetes01:30

Bacterial Phylum Spirochaetes

Spirochetes, unique bacteria in the phylum Spirochaetes, are gram-negative, motile, tightly coiled, slender, and flexible. They inhabit aquatic sediments and animals, with some causing diseases like syphilis. Spirochetes are classified into eight genera based on habitat, pathogenicity, phylogeny, and characteristics.Their distinctive motility arises from endoflagella, located within the cell’s periplasm. These endoflagella anchor at the cell poles and extend along the cell length, encased by a...
Bacterial Meningitis II: Pathophysiology01:26

Bacterial Meningitis II: Pathophysiology

Bacterial meningitis typically begins when pathogens such as Neisseria meningitidis and Streptococcus pneumoniae colonize the nasopharynx and invade the bloodstream. This process is facilitated by bacterial virulence factors, such as polysaccharide capsules, which resist phagocytosis and complement-mediated killing. Less commonly, bacteria reach the central nervous system via contiguous spread from infections like otitis media or sinusitis, through congenital or acquired dural defects, or...
Bacterial Phylum Actinobacteria01:30

Bacterial Phylum Actinobacteria

Coryneform bacteria are gram-positive, aerobic, nonmotile rods that exhibit irregular, club-shaped, or V-shaped arrangements. Their V-shape results from snapping division, where the inner cell wall layer forms the cross-wall, while the outer layer remains intact until it ruptures on one side, causing the daughter cells to bend away.The primary genera are Corynebacterium and Arthrobacter. Corynebacterium includes diverse species, ranging from saprophytes to pathogens like Corynebacterium...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Author Correction: Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity.

Scientific reports·2022
Same author

Improving outcomes in acute and chronic periprosthetic hip and knee joint infection with a multidisciplinary approach.

Bone & joint open·2021
Same author

Author Correction: Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity.

Scientific reports·2021
Same author

Hypervirulent pneumococcal serotype 1 harbours two pneumolysin variants with differential haemolytic activity.

Scientific reports·2020
Same author

A highly conserved complete accessory Escherichia coli type III secretion system 2 is widespread in bloodstream isolates of the ST69 lineage.

Scientific reports·2020
Same author

Dual RNA-seq in Streptococcus pneumoniae Infection Reveals Compartmentalized Neutrophil Responses in Lung and Pleural Space.

mSystems·2019
Same journal

Applications of lupeol to manage fungal infections: a promising multi-target molecule.

Future microbiology·2026
Same journal

Benzyl isothiocyanate-loaded chitosan beads: a novel strategy to combat biofilm formation by <i>Staphylococcus aureus</i> and <i>Escherichia coli</i>.

Future microbiology·2026
Same journal

<i>Mycobacterium colombiense</i> isolation among people living with human immunodeficiency virus: a case series.

Future microbiology·2026
Same journal

Thwarting the biothreat in the 21st century: means and methods.

Future microbiology·2026
Same journal

The oral-respiratory interface: modulation of <i>Streptococcus pneumoniae</i> serotype adhesion by the periodontal pathogen <i>Porphyromonas gingivalis</i> W83.

Future microbiology·2026
Same journal

Global One Health genomics identify conserved virulence and mobile resistance in the opportunistic pathogen <i>Staphylococcus saprophyticus</i>.

Future microbiology·2026
See all related articles

Related Experiment Video

Updated: May 26, 2026

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43
06:06

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43

Published on: September 11, 2020

What is different about serotype 1 pneumococci?

Neil D Ritchie1, Tim J Mitchell, Tom J Evans

  • 1Institute of Infection, Immunity & Inflammation, University of Glasgow, UK.

Future Microbiology
|December 24, 2011
PubMed
Summary
This summary is machine-generated.

Serotype 1 Streptococcus pneumoniae causes invasive pneumococcal disease, often in young patients, with unique T-cell dependent antigen properties. While mortality is lower, complications like empyema are common, especially in Africa.

More Related Videos

Capsular Serotyping of Streptococcus pneumoniae Using the Quellung Reaction
04:25

Capsular Serotyping of Streptococcus pneumoniae Using the Quellung Reaction

Published on: February 24, 2014

Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination
09:11

Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination

Published on: September 25, 2014

Related Experiment Videos

Last Updated: May 26, 2026

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43
06:06

Constructing Mutants in Serotype 1 Streptococcus pneumoniae strain 519/43

Published on: September 11, 2020

Capsular Serotyping of Streptococcus pneumoniae Using the Quellung Reaction
04:25

Capsular Serotyping of Streptococcus pneumoniae Using the Quellung Reaction

Published on: February 24, 2014

Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination
09:11

Capsular Serotyping of Streptococcus pneumoniae by Latex Agglutination

Published on: September 25, 2014

Area of Science:

  • Microbiology
  • Immunology
  • Epidemiology

Background:

  • Serotype 1 Streptococcus pneumoniae is a significant cause of invasive pneumococcal disease (IPD).
  • It is rarely associated with asymptomatic nasopharyngeal carriage.
  • IPD caused by serotype 1 is more prevalent in young, otherwise healthy individuals and has a lower mortality rate compared to other serotypes.

Purpose of the Study:

  • To highlight the distinct clinical and immunological characteristics of serotype 1 Streptococcus pneumoniae.
  • To explore the unique antigenic properties of the serotype 1 capsular polysaccharide.
  • To investigate potential differences in virulence factors, such as pneumolysin, among serotype 1 isolates.

Main Methods:

  • Review of clinical data on invasive pneumococcal disease cases.
  • Analysis of the structural and functional properties of the serotype 1 capsular polysaccharide.
  • Comparative analysis of virulence factors, including pneumolysin, in serotype 1 isolates.

Main Results:

  • Serotype 1 Streptococcus pneumoniae infections are frequently observed in young patients without comorbidities.
  • Empyema and extrapulmonary manifestations are common sequelae of serotype 1 IPD.
  • The serotype 1 capsular polysaccharide exhibits a zwitterionic structure, allowing it to act as a T-cell dependent antigen, unlike other pneumococcal serotypes.

Conclusions:

  • Serotype 1 Streptococcus pneumoniae possesses unique immunological and clinical features.
  • Further research is needed to determine the clinical significance of variations in pneumolysin and the T-cell dependent nature of its capsular polysaccharide.