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09:41
Preparation and Immunostaining of Myelinating Organotypic Cerebellar Slice Cultures
Published on: March 20, 2019
Molecular mechanisms regulating myelination in the peripheral nervous system
Jorge A Pereira1, Frédéric Lebrun-Julien, Ueli Suter
1Institute of Cell Biology, Department of Biology, Swiss Federal Institute of Technology, ETH Zürich, Zürich, Switzerland.
Trends in Neurosciences
|December 24, 2011
Summary
This review explores peripheral nervous system myelination, detailing how Schwann cells (SCs) interact with axons. It highlights molecular mechanisms controlling SC biology and nerve fiber function.
Area of Science:
- Neuroscience
- Cell Biology
- Molecular Biology
Background:
- Glial cells and neurons engage in bidirectional communication, crucial for nervous system function.
- Myelination, the wrapping of axons by glial cells, enables rapid nerve impulse transmission.
- Dysregulation of myelination underlies neurological disorders like multiple sclerosis and peripheral neuropathies.
Purpose of the Study:
- To present a conceptual framework integrating signaling mechanisms and Schwann cell (SC) biology in peripheral nervous system (PNS) myelination.
- To highlight key signaling hubs and molecular controls governing SC-axon interactions.
Main Methods:
- This review synthesizes existing research on PNS myelination.
- Focuses on signaling pathways and molecular mechanisms regulating SCs and axons.
Main Results:
- Identifies critical signaling hubs and molecular mechanisms controlling SC biology.
- Explains the interplay between SCs, axons, extracellular signals, and transcriptional networks.
Conclusions:
- A comprehensive understanding of PNS myelination requires integrating SC biology with signaling pathways.
- Genetic, epigenetic, and post-translational controls are vital for regulating myelination and preventing neurological diseases.
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