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A practice-based trial of blood pressure control in African Americans (TLC-Clinic): study protocol for a randomized

Antoinette Schoenthaler1, Leanne Luerassi, Jeanne A Teresi

  • 1Center for Healthful Behavior Change, New York University School of Medicine, Department of Medicine, Division of General Internal Medicine, New York, NY, USA. Antoinette.Schoenthaler@nyumc.org

Trials
|December 24, 2011
PubMed

Insights

This study tested a lifestyle intervention for uncontrolled hypertension in African Americans. The MINT-TLC program improved blood pressure control and lifestyle behaviors in participants.

Area of Science:

  • Public Health
  • Cardiovascular Medicine
  • Behavioral Science

Background:

  • Hypertension (HTN) is a major public health issue in the US, with significant morbidity, mortality, and economic costs.
  • African Americans experience a disproportionately higher burden of HTN-related outcomes.
  • Therapeutic lifestyle changes (TLC) are proven to reduce blood pressure (BP), but their effectiveness in primary care, particularly for African Americans, is understudied.

Purpose of the Study:

  • To test the effectiveness of a practice-based comprehensive therapeutic lifestyle intervention (MINT-TLC) versus Usual Care (UC) for uncontrolled hypertension in low-income African Americans.
  • To assess the impact of MINT-TLC on blood pressure reduction and key lifestyle behaviors.
  • To inform the refinement and integration of MINT-TLC into standard treatment protocols for hypertensive African Americans.

Main Methods:

  • A randomized controlled trial involving 200 low-income African Americans with uncontrolled hypertension.
  • The MINT-TLC group received 10 weekly group classes and 3 monthly individual motivational interviewing sessions.
  • The Usual Care group received a single counseling session and print materials.
  • Primary outcome: change in systolic and diastolic BP from baseline to 6 months.
  • Secondary outcomes: changes in physical activity, weight, fruit/vegetable intake, and sodium excretion.

Main Results:

  • The study is designed to provide data on the effectiveness of the MINT-TLC intervention.
  • Expected results will include changes in blood pressure and lifestyle behaviors at 6 months.
  • Analysis will focus on within-patient changes from baseline.

Conclusions:

  • This trial will yield crucial data for refining the MINT-TLC intervention.
  • Findings will guide the integration of MINT-TLC into standard care for hypertensive African Americans.
  • The study aims to maximize the translation of MINT-TLC into effective clinical practice.
Abstract

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