Chromium and genomic stability
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Updated: May 26, 2026

Rapid Analysis of Chromosome Aberrations in Mouse B Lymphocytes by PNA-FISH
Published on: August 19, 2014
Sandra S Wise1, John Pierce Wise
1Wise Laboratory of Environmental and Genetic Toxicology, Maine Center for Toxicology and Environmental Health, and Department of Applied Medical Sciences, University of Southern Maine, 96 Falmouth St., Portland, ME 04104, United States.
Abstract:
Many metals serve as micronutrients which protect against genomic instability. Chromium is most abundant in its trivalent and hexavalent forms. Trivalent chromium has historically been considered an essential element, though recent data indicate that while it can have pharmacological effects and value, it is not essential. There is no data indicating that trivalent chromium promotes genomic stability and, instead may promote genomic instability. Hexavalent chromium is widely accepted as highly toxic and carcinogenic with no nutritional value. Recent data indicate that it causes genomic instability and also has no role in promoting genomic stability.
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