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Related Concept Videos

Immune Surveillance by NK Cells and Phagocytes01:25

Immune Surveillance by NK Cells and Phagocytes

Immune surveillance is an integral part of the innate immune system, involving the continuous monitoring of peripheral tissues to detect and respond to pathogens, infected cells, or cancerous cells. This surveillance is conducted primarily by natural killer (NK) cells and phagocytes, which employ distinct but complementary mechanisms to identify and eliminate threats.
Natural Killer Cells: The Fast Responders
NK cells are large granular lymphocytes found in the blood and lymphatic system. These...
Phagocytosis00:41

Phagocytosis

Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis ("cellular eating") is one of three major types of endocytosis. Cells use phagocytosis to take in large objects, such as other cells (or their debris), bacteria, and even viruses.
The objective of phagocytosis is often destruction. Cells use phagocytosis to eliminate unwelcome visitors, like pathogens (e.g., viruses and bacteria). Many immune system cells, including...
Phagocytosis00:41

Phagocytosis

Cells pull particles inward and engulf them in spherical vesicles in an energy-requiring process called endocytosis. Phagocytosis (“cellular eating”) is one of three major types of endocytosis. Cells use phagocytosis to take in large objects—such as other cells (or their debris), bacteria, and even viruses.
Cell Migration01:09

Cell Migration

Cell migration, the process by which cells move from one location to another, is essential for the proper development and viability of organisms throughout their life. When cells are not able to migrate properly to their ordained locations, various disorders may occur. For example, disruption in cell migration causes chronic inflammatory diseases such as arthritis.
Cell Migration01:19

Cell Migration

Cell migration is a process by which the cells move from one location to another, playing an essential role in embryological development, repair and regeneration, immune response, and metastasis. Cells migrate in response to chemical or mechanical signals generated by specific organs or tissues. The overall mechanism includes three steps - polarization, protrusion, and release. Polarization involves the formation of a distinct cell front and rear, which determines the direction of movement.
Chemotaxis and Direction of Cell Migration01:21

Chemotaxis and Direction of Cell Migration

Cells can detect chemical cues in their environment and reorganize the cytoskeleton to migrate toward them or away from them. This directional migration, called chemotaxis, is essential during embryogenesis and development, immune response, tissue repair and regeneration, and reproduction. These chemical cues can either attract or repel the cell's movement. For example, axon development is determined by a combination of chemoattractants and chemorepellents that direct the growing axon towards...

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Updated: May 26, 2026

Real-Time In Vitro Migration Assay for Primary Murine CD8+ T Cells
06:42

Real-Time In Vitro Migration Assay for Primary Murine CD8+ T Cells

Published on: May 24, 2024

[Phagocyte migration: an overview].

Véronique Le Cabec1, Emeline Van Goethem, Romain Guiet

  • 1CNRS, UMR 5089, Institut de Pharmacologie et de Biologie Structurale, 205, route de Narbonne, BP 64182, F-31077 Toulouse Cedex 4, France.

Medecine Sciences : M/S
|December 24, 2011
PubMed
Summary
This summary is machine-generated.

Phagocyte infiltration is crucial for host defense and tissue repair but also drives disease progression. Understanding phagocyte migration mechanisms in 3D tissues is key to developing new therapeutic targets.

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Last Updated: May 26, 2026

Real-Time In Vitro Migration Assay for Primary Murine CD8+ T Cells
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Published on: May 24, 2024

Time-lapse Imaging of Mouse Macrophage Chemotaxis
09:33

Time-lapse Imaging of Mouse Macrophage Chemotaxis

Published on: April 2, 2020

Visualizing the Early Stages of Phagocytosis
08:04

Visualizing the Early Stages of Phagocytosis

Published on: February 3, 2017

Area of Science:

  • Immunology
  • Cell Biology
  • Pathology

Context:

  • Phagocytes are essential for host defense, bactericidal activity, and tissue repair.
  • Phagocyte infiltration into tissues contributes to the progression of diseases like cancer and chronic inflammation.
  • Understanding the molecular and cellular mechanisms controlling phagocyte tissue recruitment is critical for identifying novel therapeutic strategies.

Purpose:

  • To provide a state-of-the-art review of phagocyte tissue recruitment in vivo and in vitro models.
  • To focus on recent advancements in understanding phagocyte migration within three-dimensional (3D) environments.
  • To discuss the distinct migration modes (amoeboid and mesenchymal) employed by phagocytes, particularly macrophages.

Summary:

  • This review synthesizes current knowledge on phagocyte recruitment, emphasizing their migration through interstitial tissues.
  • It details the steps involved in phagocyte extravasation from blood vessels into tissues.
  • Recent data on 3D migration, including the roles of podosomes and proteases in mesenchymal migration by macrophages, are highlighted.

Impact:

  • Provides a comprehensive overview of phagocyte migration, crucial for both physiological and pathological processes.
  • Identifies key molecular and cellular mechanisms governing phagocyte infiltration.
  • Offers insights for the development of targeted therapies aimed at modulating phagocyte function in disease states.