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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Rous Sarcoma Virus (RSV) and Cancer01:03

Rous Sarcoma Virus (RSV) and Cancer

Rous Sarcoma virus or RSV was discovered by F. Peyton Rous in the year 1911 as a filterable transmissible agent that could cause tumors in chickens. He won a Nobel Prize for this discovery in 1966. His experiments clearly demonstrated that some cancers could be caused by infectious agents and led to the discovery of many more cancer-causing viruses in animals as well as humans.
RSV is a retrovirus that contains two copies of a plus-strand  RNA genome. Its genome consists of four main open...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...

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Related Experiment Video

Updated: May 26, 2026

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
06:15

Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia

Published on: August 9, 2024

[Dermatofibrosarcoma protuberans in children].

O Abdel Wahab1, A Qassemyar, M Maillet

  • 1Service de chirurgie plastique, reconstructrice et esthétique, hôpital Roger-Salengro, Lille, France. abdelomar@hotmail.com

Annales De Chirurgie Plastique Et Esthetique
|December 24, 2011
PubMed
Summary
This summary is machine-generated.

Dermatofibrosarcoma protuberans in children is treated effectively with wide surgical excision, similar to adults. Early diagnosis and management are crucial for optimal outcomes in pediatric cases.

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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

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Anterior High-Resolution Optical Coherence Tomography in the Diagnosis and Therapeutic Monitoring of Ocular Surface Squamous Neoplasia
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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma
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Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Area of Science:

  • Pediatric Oncology
  • Surgical Oncology
  • Dermatopathology

Background:

  • Dermatofibrosarcoma protuberans (DFSP) is a rare, locally invasive skin malignancy.
  • Pediatric cases of DFSP are infrequently documented, necessitating further research into optimal management.

Observation:

  • Fifteen pediatric patients diagnosed with DFSP between 1995 and 2008 were included in the study.
  • The mean age at diagnosis was 13 years, with lesions predominantly located on the trunk (60%).
  • Diagnosis was confirmed via biopsy and fluorescence in situ hybridization (FISH), with a history of skin trauma noted in some cases.

Findings:

  • Surgical excision with 3 cm margins and removal of the superficial anatomical layer was the primary treatment.
  • Reconstruction methods were tailored to defect size and location.
  • A mean follow-up of 7.8 years revealed no relapses within 3 years; complications included scar dehiscence and alopecia, managed successfully.

Implications:

  • Pediatric DFSP exhibits similar clinical presentation and behavior to adult DFSP, supporting analogous treatment approaches.
  • Prompt diagnosis and aggressive surgical management are vital for preventing recurrence and ensuring favorable outcomes in children.
  • This study underscores the importance of considering DFSP in pediatric differential diagnoses for persistent skin lesions.