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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer

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Optimising repeat prostate biopsy decisions and procedures.

Roger Kirby1, John M Fitzpatrick

  • 1The Prostate Centre, 32 Wimpole Street, London W1G 8GT, UK. rogerkirby@theprostatecentre.com

BJU International
|December 24, 2011
PubMed
Summary
This summary is machine-generated.

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Repeat prostate biopsies can be uncertain. Optimizing procedures with MRI and diagnostic markers like Prostate Cancer gene 3 (PCA3) improves accuracy and reduces unnecessary biopsies.

Area of Science:

  • Urology
  • Oncology
  • Medical Diagnostics

Background:

  • Men with prior negative prostate biopsies and persistent cancer suspicion face uncertainty regarding repeat biopsies.
  • Repeat biopsies carry risks of anxiety, discomfort, and complications, including hospitalization.
  • Current strategies for repeat prostate biopsy decision-making require optimization.

Purpose of the Study:

  • To review strategies for optimizing repeat prostate biopsy procedures.
  • To enhance the prediction of repeat prostate biopsy outcomes.
  • To reduce the number of unnecessary and uncomfortable repeat biopsies.

Main Methods:

  • Literature search of original and review articles on repeat prostate biopsies in PubMed.
  • Analysis of strategies including adjusting biopsy core location and number.

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Microarray-based Identification of Individual HERV Loci Expression: Application to Biomarker Discovery in Prostate Cancer
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  • Evaluation of diagnostic markers such as Prostate Cancer gene 3 (PCA3) Assay.

    • Main Results:

    • Optimizing biopsy procedures involves appropriate indications, core adjustments, and MRI utilization.
    • The Prostate Cancer gene 3 (PCA3) Assay is highly specific for prostate cancer.
    • A higher PCA3 Score predicts a positive repeat biopsy, and its inclusion in models improves predictive accuracy.

    Conclusions:

    • Optimizing repeat prostate biopsy procedures and incorporating diagnostic markers like PCA3 can improve positive biopsy rates.
    • These strategies can decrease the number of unnecessary and uncomfortable biopsies for patients.
    • PCA3 Score shows potential in guiding repeat biopsy decisions and predicting future outcomes.