Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Single Cell Analysis of the Tumor Microenvironment Landscape Across the Disease Spectrum of Multiple Myeloma.

Blood·2026
Same author

Carfilzomib, lenalidomide, and dexamethasone (KRd) versus bortezomib, lenalidomide, and dexamethasone (VRd) induction prior to autologous haematopoietic stem cell transplant/transplantation in newly diagnosed multiple myeloma.

British journal of haematology·2026
Same author

A Simplified Frailty Score Predicts Outcomes in Newly Diagnosed Multiple Myeloma Patients Undergoing Upfront Autologous Hematopoietic Stem Cell Transplantation.

Transplantation and cellular therapy·2026
Same author

Real-World Outcomes with BCMA- and GPRC5D-Targeting Bispecific Antibodies in Plasma Cell Leukemia.

Blood advances·2026
Same author

D-VRD vs. D-KRD induction in transplant-eligible multiple myeloma: a real-world comparison.

Leukemia & lymphoma·2026
Same author

D-VRD induction and autologous transplant in patients ≥70 years.

Blood cancer journal·2026

Related Experiment Video

Updated: May 26, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
03:23

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Increased eosinophilic responses in splenectomized patients.

Leor Perl1, Oren Pasvolsky1, Lilach Lifshitz2

  • 1Department of Medicine, Meir Medical Center, Kfar-Saba, Israel.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|December 24, 2011
PubMed
Summary
This summary is machine-generated.

The spleen helps control eosinophil levels in the blood. Its removal can lead to increased eosinophilia, especially during infection or stress, suggesting a role in immune regulation.

More Related Videos

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

Related Experiment Videos

Last Updated: May 26, 2026

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis
03:23

Three-Dimensional Cell Culture Models to Investigate the Epithelial Barrier in Eosinophilic Esophagitis

Published on: May 10, 2024

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation
08:44

Identification and Characterization of Immunogenic RNA Species in HDM Allergens that Modulate Eosinophilic Lung Inflammation

Published on: May 30, 2020

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination
09:38

Determining Immune System Suppression versus CNS Protection for Pharmacological Interventions in Autoimmune Demyelination

Published on: September 12, 2016

Area of Science:

  • Immunology
  • Hematology

Background:

  • The spleen is a vital immune organ, and its removal (splenectomy) increases infection susceptibility.
  • Limited evidence suggests a role for the spleen in regulating eosinophil responses, primarily from animal studies.

Purpose of the Study:

  • To investigate the impact of the human spleen on circulating eosinophil counts.
  • To determine if splenectomy affects eosinophil levels in patients.

Main Methods:

  • Retrospective analysis of 29 patients who underwent splenectomy (2000-2010).
  • Comparison of pre- and post-splenectomy eosinophil counts with control values.
  • Review of clinical data for hypereosinophilia events.

Main Results:

  • Splenectomy was associated with a higher incidence of eosinophilia compared to normal individuals.
  • Eight out of 29 splenectomized patients experienced peak eosinophil counts over 1,000/mm³.
  • Elevated eosinophil levels were frequently observed perioperatively or during acute infections.

Conclusions:

  • Impaired control of eosinophilic responses is a lasting effect of splenectomy.
  • The spleen plays a significant role in maintaining normal eosinophil levels.
  • Eosinophils may contribute to adverse outcomes following spleen removal.