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Vessel-sparing Excision and Primary Anastomosis
Published on: January 7, 2019
Coronary stent management in elective genitourinary surgery
Angela D Gupta1, Michael Streiff, Jon Resar
1Departments of Urology, Johns Hopkins Medical Institutions, Baltimore, MD 21287, USA. agupta45@jhmi.edu
Insights
Patients with coronary stents undergoing urological surgery require careful management of antiplatelet therapy. This protocol guides decisions based on procedure bleeding risk to balance stent thrombosis and surgical bleeding risks.
Area of Science:
- Cardiology
- Urology
- Surgical Management
Background:
- Dual antiplatelet therapy (DAPT) withdrawal post-stenting increases adverse coronary events.
- Patients with coronary stents undergoing surgery face increased bleeding risks.
- Multidisciplinary management is crucial for patients with coronary stents needing urological procedures.
Purpose of the Study:
- To review literature on coronary stents and genitourinary surgery.
- To provide a perioperative management protocol for patients with coronary stents undergoing urological procedures.
Main Methods:
- Literature search using keywords: 'elective surgery', 'aspirin', 'clopidogrel', 'guidelines for percutaneous coronary intervention', 'antiplatelet therapy after coronary stent placement'.
- Classification of urological procedures into low-, moderate-, and high-bleeding risk categories.
- Development of a protocol based on stent type, procedure risk, and timing.
Main Results:
- Elective procedures should be delayed: 1 month (bare-metal stent) and 1 year (drug-eluting stent).
- Low-risk procedures: Continue aspirin; DAPT 24-48h post-op if no bleeding.
- Moderate-risk procedures: Discontinue DAPT 5-7 days pre-op, resume within 7 days.
- High-risk procedures: Discontinue DAPT 10 days pre-op, resume within 7-10 days.
Conclusions:
- A multidisciplinary approach and a risk-stratified protocol enable safe surgical intervention.
- The protocol aims to balance the risks of stent thrombosis and surgical bleeding.
- Adequate stent endothelialization is key for safe surgical intervention.
Abstract:
What's known on the subject? and What does the study add? Withdrawal of dual antiplatelet therapy before the recommended, 12 months for drug-eluting stents and 1 month for bare-metal stents increases the rate of major adverse coronary events and mortality. However, in those undergoing surgery the risk of bleeding is increased substantially for those on antiplatelet agents. Successful management in patients with coronary stents who must undergo elective or non-elective urological surgery should be a multidisciplinary decision. This article reviews the literature and recommends a protocol for clinical management of patients undergoing urological procedures after coronary stent placement. To review the literature on coronary stents and genitourinary surgery and provide a protocol for perioperative. The keywords, 'elective surgery', 'aspirin', 'clopidogrel', 'guidelines for percutaneous coronary intervention', and 'antiplatelet therapy after coronary stent placement' were used to search PubMed for any relevant articles relating to coronary stents. Recommendations were made based on the whether the procedures patients were exposed to placed them at low-, moderate- or high-bleeding risk based on the extent of the procedure. All elective procedures should be delayed for 1 month after bare-metal stent placement and 1 year after drug-eluting stent placement. In patients classified as low risk (endoscopy and laser prostatectomy), aspirin should be continued throughout the perioperative period and dual antiplatelet therapy should continue 24-48 h postoperatively, if there is no concern for active bleeding. In those classified as moderate risk (scrotal procedures, transurethral resection of bladder tumours, transurethral resection of the prostate, urinary sphincter placement) dual antiplatelet therapy should be discontinued 5-7 days before the procedure and continued within 7 days after procedure, if there is no concern for active bleeding, in consultation with cardiology. In high-risk procedures (cystectomy, nephrectomy, prostatectomy, penile prosthesis placement) dual antiplatelet therapy should be discontinued 10 days before the procedure and continued postoperatively within 7-10 days of the procedure, when there is no longer a concern for active bleeding with the assistance of a cardiologist. Coronary artery disease is becoming more prominent in our society, increasing the use of coronary stents and antiplatelet agents. With the proposed protocol, it is safe to proceed with surgical intervention in those that have adequate stent endothelialisation.
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