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Related Experiment Video

Updated: May 26, 2026

Intramyocardial Cell Delivery: Observations in Murine Hearts
08:12

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Published on: January 24, 2014

Intracoronary stem-cell injection after myocardial infarction: microcirculation sub-study.

Rodrigo de Carvalho Moreira1, Andréa Ferreira Haddad, Suzana Alves Silva

  • 1Hospital Pro-Cardíaco, Botafogo, Brazil. rodrigocm@cardiol.br

Arquivos Brasileiros De Cardiologia
|December 24, 2011
PubMed
Summary

Anterograde intra-arterial coronary delivery of bone marrow mononuclear cells (BMMC) resulted in higher cardiac retention compared to the retrograde intravenous coronary route in acute myocardial infarction (AMI) patients. Both routes were feasible and safe.

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Area of Science:

  • Cardiology
  • Regenerative Medicine
  • Cell Therapy

Background:

  • Acute myocardial infarction (AMI) treatment often involves stem cell injections.
  • Intra-arterial coronary (IAC) delivery is the predominant method, while intravenous coronary (IVC) delivery is an alternative route.
  • Comparing these delivery methods is crucial for optimizing cell therapy efficacy.

Purpose of the Study:

  • To compare cell distribution and retention patterns between anterograde (IAC) and retrograde (IVC) delivery routes.
  • To assess the impact of microvascular obstruction on cell retention using cardiac MRI.
  • To evaluate the safety and feasibility of both delivery approaches in AMI patients.

Main Methods:

  • A prospective, randomized study involving 30 AMI patients with successful reperfusion.
  • 100 million bone marrow mononuclear cells (BMMC) were injected via IAC or IVC routes.
  • Cells were labeled with 99mTc-HMPAO for distribution assessment; cardiac MRI evaluated microvascular obstruction.

Main Results:

  • Both IAC and IVC routes were feasible and safe, with no serious adverse events.
  • Higher early and late retention of labeled cells was observed in the IAC group compared to the IVC group.
  • Cell retention was superior with the anterograde approach, irrespective of microcirculation obstruction.

Conclusions:

  • Retrograde IVC delivery of BMMC is a feasible and safe alternative route for AMI.
  • Anterograde IAC delivery demonstrates superior cell retention in cardiac tissue.
  • Further research is warranted to validate these findings and explore clinical implications.