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Updated: May 26, 2026

Isolation and Th17 Differentiation of Naïve CD4 T Lymphocytes
Published on: September 26, 2013
Regulation and function of innate and adaptive interleukin-17-producing cells
Keiji Hirota1, Helena Ahlfors, João H Duarte
1MRC National Institute for Medical Research, Division of Molecular Immunology, Mill Hill, London NW7 1AA, UK. khirota@nimr.mrc.ac.uk
None:
Interleukin-17 (IL-17)-mediated immune responses play a crucial role in the mucosal host defence against microbial and fungal pathogens. However, the chronic activation of IL-17-producing T helper cells can cause autoimmune disease. In addition, recent studies have highlighted key roles of innate cell-mediated IL-17 responses in various inflammatory settings. Besides inflammation, there have also been intriguing findings regarding the involvement of IL-17 responses in the pathogenesis of cardiovascular diseases and tumour formation. Here, we discuss the latest discoveries in regulation and function of innate and adaptive IL-17-producing cells.
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