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Updated: May 26, 2026

The WATCHMAN Left Atrial Appendage Closure Device for Atrial Fibrillation
Published on: February 28, 2012
Medical treatment of atrial fibrillation
A John Camm1, Christian F Camm, Irina Savelieva
1St George's Hospital, London, UK. jcamm@sgul.ac.uk
Insights
Atrial fibrillation management involves pharmacological and interventional approaches. Current antiarrhythmic drugs are often inadequate, necessitating guideline revisions for effective atrial fibrillation treatment.
Area of Science:
- Cardiology
- Electrophysiology
Background:
- Atrial fibrillation (AF) is a prevalent arrhythmia linked to significant cardiovascular disease burden.
- Current treatments include pharmacological therapies and emerging interventional techniques like ablation and left atrial appendage occlusion.
- Primary prevention strategies targeting atrial substrate are also evolving.
Purpose of the Study:
- To provide a contemporary, evidence-based review of medical management for atrial fibrillation.
- To discuss current therapeutic strategies, including rate and rhythm control.
- To highlight the challenges and evolving landscape of AF treatment.
Main Methods:
- Review of contemporary medical literature and clinical guidelines.
- Analysis of pharmacological and interventional treatment options for atrial fibrillation.
- Discussion of evidence supporting different management strategies.
Main Results:
- Pharmacological therapy for AF includes rate and rhythm control, but antiarrhythmic drugs have limitations.
- Interventional procedures are gaining popularity for AF management.
- Existing guidelines require updates due to rapid advancements in AF treatments.
Conclusions:
- Medical management of atrial fibrillation faces challenges with current antiarrhythmic drugs.
- A need exists for updated guidelines to reflect new treatments and accumulated experience.
- This review offers insights into modern, evidence-based medical management of atrial fibrillation.
Abstract:
Atrial fibrillation is an increasingly common arrhythmia which is associated with a substantial burden of cardiovascular disease. The arrhythmia is mostly treated with pharmacological therapy, although some interventional techniques such as left atrial ablation, atrioventricular nodal ablation plus pacemaker implantation, and left atrial appendage occlusion or excision are gaining popularity. The concept of primary prevention of atrial fibrillation with therapies targeting the formation and progression of atrial substrate has also recently evolved. Medical treatment is directed at either rate control (slowing the ventricular rate and allowing atrial fibrillation to continue) or rhythm control (restoring and maintaining sinus rhythm). There are different types of therapy for each purpose. Antiarrhythmic drug therapy, however, is difficult and inadequate with the agents that are now available. Treatment may be ineffective or complicated by cardiac or extracardiac adverse effects. Guidelines exist to help physicians choose appropriate therapies, but they have required and continue to need revision to cope with the rapid development and accumulating experience with new treatments. This review provides a contemporary evidence-based insight into the medical management of atrial fibrillation in the modern era.
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