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Association between HLA-Cw*0602 polymorphism and psoriasis risk: a meta-analysis
Genetics and Molecular Research : GMR
|December 24, 2011
Summary
The human leukocyte antigen (HLA) Cw*0602 polymorphism is a significant risk factor for developing psoriasis. This genetic variant increases the likelihood of developing psoriasis, as confirmed by a comprehensive meta-analysis.
Area of Science:
- Immunogenetics
- Dermatology
- Genetic Epidemiology
Background:
- Psoriasis is a chronic inflammatory skin disease with a complex etiology.
- The human leukocyte antigen (HLA) Cw*0602 polymorphism has been investigated as a potential genetic risk factor for psoriasis.
- Previous studies on the association between HLA-Cw*0602 and psoriasis risk have yielded inconsistent results.
Purpose of the Study:
- To conduct a meta-analysis to clarify the association between HLA-Cw*0602 polymorphism and psoriasis risk.
- To provide a pooled estimate of the risk conferred by HLA-Cw*0602 in a large cohort.
Main Methods:
- A systematic literature search was performed to identify relevant studies.
- Eighteen studies comprising 3419 psoriasis patients and 3297 healthy controls were included.
- Pooled odds ratios (OR) and 95% confidence intervals (95%CI) were calculated to assess the association.
Main Results:
- Significant associations were found between HLA-Cw*0602 polymorphism and psoriasis risk across various genetic models.
- Positive versus negative alleles: OR = 4.55, 95%CI = 3.65-5.67, P < 0.00001.
- Positive homozygote versus negative homozygote: OR = 23.03, 95%CI = 13.95-38.00, P < 0.00001.
Conclusions:
- The positive allele of HLA-Cw*0602 polymorphism is a significant risk factor for psoriasis.
- This finding supports the role of specific HLA alleles in the genetic susceptibility to psoriasis.
- Further research may explore the functional mechanisms linking HLA-Cw*0602 to psoriasis pathogenesis.
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