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Sulcus vocalis: evidence for autosomal dominant inheritance
R H G Martins1, T M Gonçalves, D S Neves
1Departamento de Otorrinolaringologia, Faculdade de Medicina de Botucatu, Universidade Estadual de São Paulo Júlio de Mesquita Filho, Botucatu, SP, Brasil.
Genetics and Molecular Research : GMR
|December 24, 2011
Summary
This study suggests sulcus vocalis may be inherited in an autosomal dominant pattern. Evidence from one family across three generations indicates a hereditary basis for this vocal cord condition.
Area of Science:
- Otolaryngology
- Genetics
- Medical Science
Background:
- Sulcus vocalis is a laryngeal condition affecting vocal fold vibration.
- The etiology of sulcus vocalis is not fully understood, with various contributing factors proposed.
Purpose of the Study:
- To investigate the potential hereditary transmission of sulcus vocalis.
- To propose an etiological model for sulcus vocalis based on family pedigree analysis.
Main Methods:
- Clinical examination of four dysphonic patients from three generations of a single family.
- Videolaryngoscopy and direct laryngoscopy were utilized for diagnosis.
Main Results:
- Sulcus vocalis was diagnosed in all four examined patients.
- The affected individuals spanned three generations, demonstrating vertical transmission in both males and females.
Conclusions:
- The observed pattern of inheritance strongly suggests an autosomal dominant mode for sulcus vocalis.
- This family pedigree provides evidence for a genetic basis of sulcus vocalis.
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