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Updated: May 26, 2026

Investigating the Pathogenesis of MYH7 Mutation Gly823Glu in Familial Hypertrophic Cardiomyopathy using a Mouse Model
Published on: August 8, 2022
Hypertrophic cardiomyopathy: a real risk factor for stroke
R A Badawi1, S Seetharaman, J Birns
1Department of Interventional Cardiology, The John Ochsner Heart & Vascular Institute, New Orleans, LA 70121, USA. rbadawi@msn.com
Hypertrophic cardiomyopathy patients often miss stroke prevention due to under-recognized risks. Early anticoagulation is crucial for managing this complex heart condition and preventing ischaemic stroke.
Area of Science:
- Cardiology
- Cardiovascular Medicine
- Clinical Science
Background:
- Hypertrophic cardiomyopathy (HCM) is a prevalent and multifaceted cardiovascular disease.
- HCM presents as a complex, heterogeneous condition affecting the heart muscle.
Observation:
- The link between hypertrophic cardiomyopathy and ischaemic stroke is frequently overlooked.
- Atrial fibrillation is also a common comorbidity in HCM patients.
- These associations are often under-recognized in clinical practice.
Findings:
- Many patients with HCM who are at risk for stroke are not receiving appropriate oral anticoagulation therapy.
- This under-treatment increases the risk of preventable ischaemic stroke events.
Implications:
- There is a critical need to improve awareness and diagnosis of stroke risk in HCM.
- Implementing timely oral anticoagulation can significantly reduce stroke incidence in affected individuals.
- Enhanced clinical protocols are required for comprehensive HCM patient management.
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