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Endocrine diarrhoeas: current concepts.

S C Misra1

  • 1Department of Gastroenterology, AIIMS, New Delhi, India.

Tropical Gastroenterology : Official Journal of the Digestive Diseases Foundation
|April 1, 1990
PubMed
Summary
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Chronic diarrhea in endocrine disorders, especially neuroendocrine tumors, is caused by circulating agents affecting gut function. This review covers diarrhea characteristics, pathogenesis, and treatment strategies for these conditions.

Area of Science:

  • Endocrinology
  • Gastroenterology
  • Oncology

Background:

  • Chronic diarrhea is a significant symptom in various endocrine gland disorders.
  • Gut neuroendocrine tumors are a primary cause, releasing diverse agents that impact gastrointestinal function.

Purpose of the Study:

  • To review the characteristics, pathogenesis, and therapeutic aspects of chronic diarrhea associated with endocrine disorders.
  • To outline diagnostic approaches, including tumor localization and anti-tumor treatment selection.

Main Methods:

  • Literature review of endocrine disorders causing chronic diarrhea.
  • Analysis of pathogenic mechanisms involving hormones, paracrine substances, neurotransmitters, and other agents.
  • Evaluation of diagnostic and therapeutic strategies.

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Main Results:

  • Identified various circulating agents (hormones, paracrine substances, neurotransmitters, unknown agents) responsible for diarrhea.
  • Detailed the characteristics and pathogenesis of diarrhea in specific endocrine syndromes and diseases.
  • Outlined diagnostic pathways and treatment options for neuroendocrine tumors and related conditions.

Conclusions:

  • Chronic diarrhea in endocrine disorders is multifactorial, often linked to gut neuroendocrine tumors.
  • Effective management requires understanding pathogenesis, accurate diagnosis, tumor localization, and tailored anti-tumor therapies.