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Retraction.

Science (New York, N.Y.)

|December 24, 2011

Summary

This summary is machine-generated.

Science has retracted a study that claimed to find the infectious retrovirus XMRV in patients with chronic fatigue syndrome. This retraction impacts retroviral research and chronic fatigue syndrome understanding.

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Area of Science:

Virology
Immunology
Epidemiology

Context:

A 2009 Science report suggested a link between the retrovirus XMRV and chronic fatigue syndrome (CFS).
This finding generated significant interest and further research into a potential infectious etiology for CFS.
Subsequent studies failed to consistently replicate the initial findings, raising questions about the original report's validity.

Purpose:

To address the scientific community's concerns regarding the reproducibility and validity of the initial XMRV detection in chronic fatigue syndrome patients.
To formally retract the original publication based on accumulating evidence and scientific consensus.
To correct the scientific record concerning the association between XMRV and CFS.

Summary:

The journal Science is retracting the 2009 report by Lombardi et al. that claimed the detection of the xenotropic murine leukemia virus-related retrovirus (XMRV) in patients with chronic fatigue syndrome.
The retraction is based on widespread failure to replicate the findings and concerns regarding the integrity of the data.
This action reflects the scientific process of self-correction when evidence suggests a prior conclusion was erroneous.

Impact:

The retraction significantly impacts the understanding of chronic fatigue syndrome, moving away from a viral cause like XMRV.
It highlights the importance of rigorous validation and reproducibility in scientific research, particularly in complex diseases.
This event underscores the challenges in retroviral research and the need for careful interpretation of initial findings.