Related Experiment Video
Updated: May 26, 2026

Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Long-term maternal depression after expectant management of early preterm birth
Devin Namaky1, Jessica Herzberg, Thomas Dehoop
1Department of Obstetrics and Gynecology, Good Samaritan Hospital, 375 Dixmyth Avenue, Cincinnati, OH 45220, USA. devin_namaky@trihealth.com
Objective:
This study was undertaken to determine factors that affect depression after delivery of infants at the limits of viability. We hypothesized that expectantly managed mothers would have lower risk of depression several years after delivery.
Study Design:
Charts were reviewed for deliveries in the calendar years 2003 through 2005 with a diagnosis of preterm labor, premature rupture of membranes or cervical insufficiency admitted at a gestation between 20 and 25(6/7) weeks. Surveys were sent that included the Edinburgh Postnatal Depression Scale and questions regarding care around the time of delivery.
Results:
A total of 176 patients met inclusion criteria. Of those, 36 consented and returned surveys. Of patients who were expectantly managed, none (0%) screened positive for depression, while 11 (38%) patients who were not expectantly management screened positive (p=0.08). Between 36 and 72 returned surveys would be needed for this to be significant, using p<0.05. Survey results indicated that 75% of respondents agreed hospitalization was traumatic, 78% would still attempt to delay birth, 97% would accept tocolysis, 89% agreed their child functioned similar to other children, and 77% were happy with how physicians handled their care.
Conclusion:
Expectant management may be associated with lower risk of depression. Larger studies evaluating psychosocial effects of interventions are justified.
Related Concept Videos
Long-term Depression
Long-term Depression
Calcium Ion Concentration Mechanism
If over time, all...
Depressive Disorders: Etiology
Biological Factors in Depression
Biological predispositions significantly influence the risk of developing depressive disorders. Genetic studies highlight the role of variations in the serotonin transporter...
Depressive Disorders: MDD and Dysthymia
Depression: Overview
Mitral Valve Prolapse III: Nursing Management

