Impact of a single endometrial injury on assisted reproductive technology outcome: a preliminary observational study

To find a more acceptable strategy for our patients to improve endometrial receptivity in assisted reproductive technologies (ART) and to study the impact of a single endometrial sampling performed on day 21 of the spontaneous menstrual cycle.

In this preliminary study, the possible beneficial effects on ART outcome of a single biopsy performed on the midluteal phase (day 21) of the spontaneous menstrual cycle preceding controlled ovarian stimulation was tested in a group of patients with 3 or more implantation failures.

After endometrial biopsy 45.94% of patients with more than two failed ART cycles obtained clinical pregnancy.

Although these preliminary results are encouraging, further investigation is needed to validate the study.