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Updated: May 26, 2026

Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells
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Published on: January 9, 2019

T cell Myc-tabolism.

Jeffrey C Rathmell1

  • 1Department of Pharmacology and Cancer Biology, Department of Immunology, Sarah W. Stedman Nutrition and Metabolism Center, Duke University, Durham, NC 27710, USA. jeff.rathmell@duke.edu

Immunity
|December 27, 2011
PubMed
Summary
This summary is machine-generated.

Myc is essential for T cell metabolic reprogramming during activation. This transcription factor drives increased glucose and glutamine metabolism to meet energy demands.

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Multicolor Flow Cytometry-based Quantification of Mitochondria and Lysosomes in T Cells
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Published on: January 9, 2019

Measuring Mitochondrial Function of Na&#239;ve and Effector CD8 T Cells
06:07

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Published on: March 28, 2025

Area of Science:

  • Immunology
  • Cellular Metabolism
  • Molecular Biology

Background:

  • T cell activation necessitates significant increases in cellular energy and biosynthesis.
  • Metabolic pathways, particularly glucose and glutamine metabolism, are upregulated to support these demands.

Discussion:

  • The study by Wang et al. (2011) investigates the role of Myc in T cell metabolic adaptation.
  • Myc's function is crucial for orchestrating the metabolic shifts required for activated T cells.

Key Insights:

  • Myc is identified as a critical regulator of T cell metabolic reprogramming.
  • This highlights Myc's importance in immune cell function and energy homeostasis.

Outlook:

  • Further research into Myc's role could reveal therapeutic targets for immune-related diseases.
  • Understanding this metabolic reprogramming is key to modulating T cell responses.