Optimization of HNO production from N,O-bis-acylated hydroxylamine derivatives
Art D Sutton1, Morgan Williamson, Hilary Weismiller
1Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, USA.
Abstract:
A wide range of N,O-bis-acylated hydroxylamine derivatives with chloro or arenesulfonyl leaving groups, and a related set of N-hydroxy-N-acylsulfonamides, have been synthesized and evaluated for nitroxyl (HNO) production. Mechanistic studies have revealed that the observed aqueous chemistry is more complicated than originally anticipated, and have been used to develop a new series of efficient HNO precursors (4u-4x, 7c-7d) with tunable half-lives.
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