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Updated: May 26, 2026

Disruption of the Mouse Blood-Brain Barrier by Small Extracellular Vesicles from Hypoxic Human Placentas
Published on: January 26, 2024
[Pathophysiology of preeclampsia: some recent data]
1Pôle de gynécologie-obstétrique, médecine fœtale, reproduction humaine et orthogénie, CHU d'Angers, Angers cedex 9, France. a.fournie@neuf.fr
Abstract:
Placental ischemia is the background of the pathophysiology of preeclampsia. It is mainly - but not exclusively - caused by an immunological conflict between maternal NK cells of the decidua and of the uterine junctional zone, and the HLA-C antigens shared by interstitial trophoblast. The maternal disease is the consequence of the placental ischemia, and is characterized by an inflammatory syndrome with an oxidative stress and an endothelial cell dysfunction. Genetics play an essential part in each of these steps.
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