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Establishment of Acute Pontine Infarction in Rats by Electrical Stimulation

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Published on: August 27, 2020

Reversible parainfectious bilateral "striatal necrosis".

Shalini Nandish¹, Rafeh Khan, Daniel J Connolly

¹Department of Neuroradiology, Children's Hospital Sheffield, Sheffield, UK.

Pediatric Neurology

|December 27, 2011

Summary

Bilateral striatal necrosis can resolve completely in children, even with severe symptoms and imaging changes. These cases show that full clinical and radiologic recovery is possible within months.

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Last Updated: May 26, 2026

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Transsynaptic Tracing from Peripheral Targets with Pseudorabies Virus Followed by Cholera Toxin and Biotinylated Dextran Amines Double Labeling

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Published on: September 14, 2015

Area of Science:

Neurology
Pediatrics
Radiology

Background:

Bilateral striatal necrosis is typically linked to toxins and poor neurodevelopmental outcomes.
Acute bilateral striatal clinical syndrome presents with movement disorders and magnetic resonance imaging (MRI) signal abnormalities.

Observation:

Two young boys presented with acute bilateral striatal syndrome after a viral illness, exhibiting speech slurring, bradykinesia, and extrapyramidal movement disorder.
Cranial MRI revealed bilateral, symmetric high signal changes in the lentiform nucleus (putamen), with globus pallidi spared.
Neurometabolic investigations were normal in both patients.

Findings:

Both patients achieved complete clinical and radiologic recovery within 3 months.
Follow-up assessments at 3 years and 1 year, respectively, showed good neurological and academic progress.
The pathogenesis remains uncertain, with an immune-mediated mechanism suggested.

Implications:

This study highlights that severe acute striatal injury on imaging does not always predict long-term deficits.
It suggests that prompt diagnosis and monitoring can lead to favorable outcomes in pediatric bilateral striatal necrosis.
The findings challenge the assumption of poor neurodevelopmental outcomes in all cases of bilateral striatal necrosis.