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Updated: May 26, 2026
Murine Fetal Echocardiography
Published on: February 15, 2013
Evaluation of 1025 fetal deaths: proposed diagnostic workup
Fleurisca J Korteweg1, Jan Jaap H M Erwich, Albertus Timmer
1Department of Obstetrics and Gynecology, University Medical Centre Groningen, University of Groningen, The Netherlands. f.j.korteweg@og.umcg.nl
Objective:
We sought to evaluate the contribution of different diagnostic tests for determining cause of fetal death. Our goal was to propose a workup guideline.
Study Design:
In a multicenter prospective cohort study from 2002 through 2008, for 1025 couples with fetal death ≥20 weeks' gestation, an extensive nonselective diagnostic workup was performed. A panel classified cause and determined contribution of diagnostics for allocating cause.
Results:
A Kleihauer-Betke, autopsy, placental examination, and cytogenetic analysis were abnormal in 11.9% (95% confidence interval [CI], 9.8-14.2), 51.5% (95% CI, 47.4-55.2), 89.2% (95% CI, 87.2-91.1), and 11.9% (95% CI, 8.7-15.7), respectively. The most valuable tests for determination of cause were placental examination (95.7%; 95% CI, 94.2-96.8), autopsy (72.6%; 95% CI, 69.2-75.9), and cytogenetic analysis (29.0%; 95% CI, 24.4-34.0).
Conclusion:
Autopsy, placental examination, cytogenetic analysis, and testing for fetal maternal hemorrhage are basic tests for workup after fetal death. Based on the results of these tests or on specific clinical characteristics, further sequential testing is indicated.
