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Updated: May 26, 2026
Flow Cytometry Analysis of Tissue Factor Expression in Human Platelets
Published on: November 22, 2024
Soluble CD40 ligand, high sensitive C-reactive protein and fetuin-A levels in patients with essential thrombocythemia
Ferda Bilgir1, Oktay Bilgir, Levent Kebapcilar
1Izmir Buca State Hospital, Department of Internal Medicine, Buca, Izmir, Turkey.
Background:
CD40 ligand (CD40L) is expressed on the surface of activated platelets and activated T lymphocytes. Circulating soluble CD40 ligand (sCD40L) is formed from these molecules proteolytically. Fetuin-A is a potent antiinflammatory cytokine.
Aim Of The Study:
In this study, we aim to investigate sCD40L levels to determine whether there is platelet activation and to measure high sensitive C-reactive protein (hs-CRP) levels to demonstrate if this leads to an inflammatory process and also to study fetuin-A levels to see if there is any concomitant antiinflammatory event in patients with essential thrombocythemia (ET).
Methods:
We compared 30 patients with essential thrombocythemia with 30 control subjects and in these patients we measured levels of sCD40L, hs-CRP and fetuin-A.
Results:
sCD40L levels were significantly higher in the ET group compared to the control group (30.6±14.4 vs. 18.5±8.9, p=0.001). Although fetuin-A levels showed a slight trend to be increased in ET patients, the difference did not reach significance (4.5±4.2 vs. 3.2±2.1, p=0.158). There were no statistically significant differences in hs-CRP levels (24.6±4.9 vs. 25.0±5.2, p=0.750).
Conclusion:
sCD40L was significantly higher in patients with an ET without any association with an inflammatory process and we believe this may be a marker of platelet regeneration.
