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Updated: May 26, 2026

An Efficient Method for the Synthesis of Peptoids with Mixed Lysine-type/Arginine-type Monomers and Evaluation of Their Anti-leishmanial Activity
Published on: November 2, 2016
In vitro and in silico studies of polycondensed diazine systems as anti-parasitic agents
Anna Maria Almerico1, Marco Tutone, Annalisa Guarcello
1Dipartimento di Scienze e Tecnologie Molecolari e Biomolecolari (STEMBIO) Sezione di Chimica Farmaceutica e Biologica, Università di Palermo Via Archirafi, 32, 90123 Palermo, Italy. annamaria.almerico@unipa.it
Abstract:
Parasitic diseases caused by protozoarian agents are still relevant today more than ever. Recently, we synthesized several polycondensed diazine derivatives by means 1,3-dipolar cycloaddition reactions. A broad selection of these compounds were submitted to in vitro biological screening against Plasmodium falciparum, Leishmania infantum, Trypanosoma brucei, and Trypanosoma cruzi, resulting active at micromolar level. Induced Fit Docking/MM-GBSA studies were performed giving interesting indications about the probable mechanism of action of the most active compounds.
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