Related Experiment Video

Updated: May 26, 2026

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin
07:38

Induction of Nephrotic Syndrome in Mice by Retrobulbar Injection of Doxorubicin and Prevention of Volume Retention by Sustained Release Aprotinin

Published on: May 6, 2018

Protective effect of Moringa oleifera leaves against gentamicin-induced nephrotoxicity in rabbits

Moustapha Ouédraogo1, Assita Lamien-Sanou, Norbert Ramdé

  • 1Laboratory of Pharmacology and Toxicology, Health Sciences Faculty, University of Ouagadougou, 03 BP 7021 Ouagadougou, Burkina Faso. mustapha_ouedraogo@yahoo.fr

Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Fur Toxikologische Pathologie
|December 27, 2011
PubMed

Insights

Moringa oleifera leaf extract protected rabbits from gentamicin-induced kidney damage. The extract reduced kidney injury markers and inhibited lipid peroxidation, suggesting a nephroprotective effect.

Area of Science:

  • Pharmacology
  • Nephrology
  • Oxidative Stress

Background:

  • Gentamicin administration can cause nephrotoxicity, potentially linked to oxidative stress.
  • Reactive oxygen species (ROS) play a role in gentamicin-induced renal injury.

Purpose of the Study:

  • To investigate the nephroprotective potential of Moringa oleifera leaf extract against gentamicin-induced renal damage in rabbits.
  • To evaluate the effect of Moringa oleifera on biochemical and histological markers of kidney injury.

Main Methods:

  • Rabbits were treated with gentamicin (80 mg/kg) and varying doses of Moringa oleifera aqueous-ethanolic extract (150 and 300 mg/kg).
  • Serum urea and creatinine levels were measured as indicators of nephrotoxicity.
  • Kidney tissues were examined histologically, and lipid peroxidation (LPO) levels were determined.

Main Results:

  • Moringa oleifera treatment significantly reduced serum urea and creatinine levels in gentamicin-treated rabbits.
  • Histological examination revealed reparative changes in the kidneys of rabbits treated with Moringa oleifera.
  • Gentamicin intoxication significantly increased kidney lipid peroxidation, which was significantly depleted by co-administration of Moringa oleifera extract.

Conclusions:

  • The aqueous-ethanolic extract of Moringa oleifera leaves exhibits significant nephroprotective effects against gentamicin-induced renal injury in rabbits.
  • Moringa oleifera may exert its protective action by inhibiting lipid peroxidation, a key factor in oxidative stress-related kidney damage.

More Related Videos

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway07:15

Mechanism of Kemeng Fang's Inhibition of Podocyte Apoptosis in Rats with Membranous Nephropathy through the PI3K/AKT Signaling Pathway

Published on: August 23, 2024

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy07:52

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy

Published on: November 7, 2017

Related Concept Videos

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations01:15

Determination of Multiple Dosing Parameters: Steady-State, Minimum and Maximum Concentrations

Gentamicin, an aminoglycoside antibiotic, is commonly administered via intermittent intravenous infusion to treat severe infections. An intermittent one-hour infusion of gentamicin, administered at eight-hour intervals, allows for precise control of plasma drug concentrations, minimizing toxicity while ensuring therapeutic efficacy. Pharmacokinetic principles govern the dynamics of plasma concentrations and can be mathematically described using specific equations.The plasma drug concentration...
Acute Kidney Injury IV: Diagnostic Studies and Prevention01:30

Acute Kidney Injury IV: Diagnostic Studies and Prevention

Accurate diagnosis and effective prevention are critical in managing Acute Kidney Injury (AKI), which is linked to high mortality rates ranging from 10% to 80%. Timely recognition of at-risk patients and careful monitoring can significantly reduce the likelihood of kidney damage.Diagnostic Assessments:The diagnostic process starts with a comprehensive medical history to identify prerenal, intrarenal, and postrenal causes.Prerenal causes, such as dehydration, hypotension, or blood loss, should...