Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cholesterol: Significance and Regulation

Cholesterol: Significance and Regulation

Although not a source of energy, cholesterol plays a significant role as a foundational structure for bile salts, steroid hormones, and vitamin D, as well as being a crucial component of plasma membranes. Approximately 15% of blood cholesterol is derived from our diet, with the remainder synthesized from acetyl CoA by the liver and intestines. Cholesterol is eliminated from the body through its conversion into bile salts, which are eventually discarded in the feces.
Considering cholesterol and...

Overview of Lipid Metabolism

Overview of Lipid Metabolism

Lipid metabolism is a crucial process in the human body that involves the synthesis and degradation of lipids. This process is essential for energy production, cell membrane formation, and hormone production, among other functions.
Lipolysis: The Breakdown of Lipids:
Lipolysis is the process of breaking down lipids, particularly triglycerides, into glycerol and fatty acids. This process typically occurs in the adipose tissue and is triggered by various hormones, including glucagon and...

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Lipid-Lowering Drugs: Statins and Miscellaneous Agents

Hyperlipidemia, a medical condition often referred to as high cholesterol, is characterized by abnormally elevated levels of lipids in the bloodstream. When present in excess, these lipids, specifically cholesterol and triglycerides, can lead to serious health complications, often involving cardiovascular diseases. Illnesses like atherosclerosis, heart attacks, and pancreatitis have all been linked to untreated hyperlipidemia. This means controlling and regulating cholesterol and triglyceride...

Blood Studies for Cardiovascular System III: Serum Lipid Profile

Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
Serum lipids are fats and fatty substances in the blood and are crucial for various bodily functions, including energy storage, cellular structure, and hormone production. Serum lipids consist of cholesterol, triglycerides, and phospholipids.
Cholesterol is a soft, fat-like substance found in all body cells. It is crucial for producing hormones, vitamin D, and substances that aid...

Lipids: Dietary Sources and Requirements

Lipids: Dietary Sources and Requirements

Lipids are an essential component of a balanced human diet. Triglycerides, which make up the majority of dietary lipids, are found in both saturated fats—commonly present in meat, dairy products, and certain tropical plants like coconut, and hydrogenated oils such as margarine and baking shortenings (trans fats)—and unsaturated fats, which are abundant in seeds, nuts, olive oil, and most vegetable oils. The main sources of cholesterol include egg yolks, various meats and organ meats, shellfish,...

Overview of Fatty Acid Metabolism

Overview of Fatty Acid Metabolism

Lipids also are sources of energy that power cellular processes. Like carbohydrates, lipids are composed of carbon, hydrogen, and oxygen, but these atoms are arranged differently. Most lipids are nonpolar and hydrophobic. Major types include fats and oils, waxes, phospholipids, and steroids.
Fatty acids are catabolized in a process called beta-oxidation, which takes place in the matrix of the mitochondria and converts their fatty acid chains into two-carbon units of acetyl groups. The acetyl...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

How to read literature: what every menopause practitioner and researcher needs to know.

Menopause (New York, N.Y.)·2026

Same author

Migraine and Stroke Risk in Postmenopausal Women in the Women's Health Initiative.

Neurology·2026

Same author

Pregnancy and breastfeeding are associated with less later-life cognitive decline in a longitudinal, prospective cohort.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026

Same author

Independent, but not synergistic, associations of <i>APOE</i>ε4 and systemic inflammation on cognitive decline: findings from the Women's Health Initiative.

Journal of clinical and experimental neuropsychology·2026

Same author

Racial differences in breast cancer-specific mortality and CVD-specific mortality after breast cancer in post-menopausal women.

Cardio-oncology (London, England)·2025

Same author

Longitudinal transitions in sedentary behavior and physical activity in relation to all-cause and cause-specific mortality among postmenopausal women.

GeroScience·2025

Search research articles

Related Experiment Video

Updated: May 26, 2026

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model

Published on: March 5, 2022

Dyslipidemia in PCOS.

Robert A Wild¹

¹Oklahoma University Health Sciences Center, Oklahoma City, OK, United States. Robert-Wild@ouhsc.eduoma

|December 27, 2011

Summary

This summary is machine-generated.

Women with Polycystic Ovary Syndrome (PCOS) experience lifelong lipid metabolic dysfunction, increasing cardiovascular disease (CVD) risk. This dysfunction, linked to insulin resistance, necessitates lifestyle interventions and potential medication to manage abnormal lipid levels.

Related Experiment Videos

Last Updated: May 26, 2026

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model

Evaluation of Hepatic Glucose Production in a Polycystic Ovary Syndrome Mouse Model

Published on: March 5, 2022

Area of Science:

Endocrinology
Metabolic Health
Cardiovascular Disease Research

Background:

Polycystic Ovary Syndrome (PCOS) is associated with lifelong lipid metabolic dysfunction.
Insulin resistance (IR), androgen excess, and hormonal fluctuations contribute to dyslipidemia in women with PCOS.
This metabolic dysfunction exacerbates the risk of cardiovascular disease (CVD) with aging.

Purpose of the Study:

To investigate the specific lipid metabolic alterations in women with PCOS.
To evaluate the association between PCOS, dyslipidemia, and cardiovascular risk markers.
To highlight the clinical implications of these metabolic changes for long-term health.

Main Methods:

Comparative analysis of lipid profiles (triglycerides, HDL-cholesterol, non-HDL cholesterol, ApoB, ApoCIII/ApoCII ratio, ApoCI) between women with PCOS and non-PCOS controls.
Assessment of common PCOS phenotypes including androgen excess and insulin resistance.
Correlation of lipid parameters and clinical factors (e.g., waist circumference) with CVD risk.

Main Results:

Women with PCOS exhibited significantly higher triglycerides, lower HDL-cholesterol, and higher non-HDL cholesterol compared to controls.
Elevated ApoCIII/ApoCII ratios and ApoCI levels were observed in women with PCOS, irrespective of obesity status.
ApoB levels correlated with non-HDL cholesterol, indicating increased atherogenic small LDL particles. Elevated triglycerides and waist circumference were identified as key CVD risk predictors.

Conclusions:

Women with PCOS have distinct, lifelong apolipoprotein lipid metabolic dysfunction contributing to heightened CVD risk.
ApoCI elevation warrants further investigation as a potential marker for PCOS-related dysfunction and CVD risk.
Aggressive management including diet, exercise, and pharmacotherapy is crucial for normalizing dyslipidemia and mitigating cardiovascular risk in women with PCOS.