Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre- and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.

Long-term Potentiation

Long-term Potentiation

Long-term potentiation, or LTP, is one of the ways by which synaptic plasticity—changes in the strength of chemical synapses—can occur in the brain. LTP is the process of synaptic strengthening that occurs over time between pre and postsynaptic neuronal connections. The synaptic strengthening of LTP works in opposition to the synaptic weakening of long-term depression (LTD) and together are the main mechanisms that underlie learning and memory.
Hebbian LTP
LTP can occur when presynaptic neurons...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Haplotype analysis of spinocerebellar ataxia type 36 suggests a shared permissive core haplotype across populations.

Journal of human genetics·2026

Same author

Age and sex-dependent alteration in AMPA receptor density in living human brain.

European journal of nuclear medicine and molecular imaging·2026

Same author

Predicting Craving-Related Emotions among Opioid Use Disorder Patients: Preliminary Results.

... International Conference on Wearable and Implantable Body Sensor Networks. International Conference on Wearable and Implantable Body Sensor Networks·2026

Same author

Sensor-Based Estimation of Dim Light Melatonin Onset (DLMO) Using Features of Two Time Scales.

ACM transactions on computing for healthcare·2026

Same author

Correction: Sleep-wake patterns are altered with age, Prdm13 signaling in the DMH and diet restriction in mice.

Life science alliance·2026

Same author

How ketamine works: An actionable hypothesis.

Proceedings of the National Academy of Sciences of the United States of America·2026

Search research articles

Related Experiment Video

Updated: May 26, 2026

A High-content Assay for Monitoring AMPA Receptor Trafficking

A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

Developmental AMPA receptor subunit specificity during experience-driven synaptic plasticity in the rat barrel

Tomoyuki Miyazaki¹, Misako Kunii, Hirobumi Tada

¹Yokohama City University Graduate School of Medicine, Department of Physiology, 3-9 Fukuura, Kanazawa-ku, Yokohama 236-0004, Japan.

|December 27, 2011

Summary

Early brain development relies on experience-driven AMPA receptor delivery. Researchers found whisker experience guides specific AMPA receptor subunits (GluR4 then GluR1) into synapses at distinct early postnatal periods.

More Related Videos

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Published on: November 11, 2017

3D Modeling of Dendritic Spines with Synaptic Plasticity

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

Related Experiment Videos

Last Updated: May 26, 2026

A High-content Assay for Monitoring AMPA Receptor Trafficking

A High-content Assay for Monitoring AMPA Receptor Trafficking

Published on: January 28, 2019

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Slice Patch Clamp Technique for Analyzing Learning-Induced Plasticity

Published on: November 11, 2017

3D Modeling of Dendritic Spines with Synaptic Plasticity

3D Modeling of Dendritic Spines with Synaptic Plasticity

Published on: May 18, 2020

Area of Science:

Neuroscience
Developmental Biology
Synaptic Plasticity

Background:

Experience shapes early brain development by influencing synaptic connections.
AMPA receptors are crucial for synaptic transmission and plasticity.
Different AMPA receptor subunits may have distinct roles in synaptic organization.

Purpose of the Study:

To investigate the subunit-specific, experience-driven delivery of AMPA receptors to synapses during early postnatal development.
To determine the temporal sequence of AMPA receptor subunit incorporation into synapses in the rat barrel cortex.

Main Methods:

Utilized virus-mediated in vivo gene delivery to express GFP-tagged AMPA receptor subunits (GluR1, GluR4) in rat cortical neurons.
Performed in vitro whole-cell recordings from acute brain slices to analyze synaptic transmission.
Examined synaptic delivery of AMPA receptors at two critical developmental periods: postnatal days 8-10 and 12-14.

Main Results:

Whisker experience promoted the synaptic delivery of GluR4 but not GluR1 at P8-P10.
At a later stage (P12-P14), whisker experience facilitated GluR1, but not GluR4, synaptic delivery.
Demonstrated a switch in AMPA receptor subunit incorporation driven by experience during development.

Conclusions:

A precise, subunit-specific developmental program governs experience-driven AMPA receptor delivery to synapses.
This temporal regulation of AMPA receptor subunits shapes the initial organization of cortical function through experience-dependent plasticity.