Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Anticoagulant Drugs: Low-Molecular-Weight Heparins01:30

Anticoagulant Drugs: Low-Molecular-Weight Heparins

Hemostasis is a crucial process that prevents excessive blood loss from damaged blood vessels. It involves various mechanisms such as vasoconstriction, platelet adhesion and activation, and fibrin formation. The importance of each mechanism depends on the type of vessel injury. In contrast, thrombosis is the abnormal formation of a blood clot within the blood vessels, leading to potential complications if the clot obstructs blood flow. Thrombosis can be caused by increased coagulability of the...
Coagulation01:06

Coagulation

Colloidal solids are solid particles suspended in solution. They are usually negatively charged, attracting a compact primary layer of positively charged ions, which attract more counterions to form an electrical double layer. Electrostatic repulsion between the charged double layers prevents the particles from colliding, stabilizing the colloids. These solids are often undesirable because they can contain toxins that are difficult to remove. Coagulation is a technique that helps aggregate and...
Formation of the Platelet Plug01:22

Formation of the Platelet Plug

The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
As the injured blood vessel contracts, endothelial cells undergo contraction, revealing collagen fibers in the basement membrane and underlying connective tissue. Furthermore, the plasma membrane of endothelial cells becomes adhesive, preparing the site for platelet adhesion. Platelets...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The chaperone DNAJB6b halts amyloid formation through association with transient Aβ oligomers.

Physical chemistry chemical physics : PCCP·2026
Same author

The temperature dependence of amyloid <i>β</i> solubility reveals the hydrophobic effect as the main driving force for fibril formation.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Rapid elongation drives the exceptionally fast aggregation of the most common localized human amyloid medin.

Communications chemistry·2026
Same author

Transient Interactions of α-Synuclein N- and C-Termini.

ACS chemical neuroscience·2026
Same author

Correction to "Design of Tau Aggregation Inhibitors Using Iterative Machine Learning and a Polymorph-Specific Brain-Seeded Fibril Amplification Assay".

Journal of the American Chemical Society·2026
Same author

Structural defects in amyloid-β fibrils drive secondary nucleation.

Nature communications·2026
Same journal

Dual PLGA nanoparticles co-encapsulating P5091 and Resveratrol synergistically target the USP7-MDM2-P53 axis for glioma therapy.

Nanomedicine : nanotechnology, biology, and medicine·2026
Same journal

Regenerative polymer-based modalities for diabetic foot ulcers: From material design to clinical translation.

Nanomedicine : nanotechnology, biology, and medicine·2026
Same journal

Mentha-derived green synthesized ZnO nanoparticles potentiate methotrexate induced molecular and migratory inhibition via gene expression modulation in T24 bladder cancer cells.

Nanomedicine : nanotechnology, biology, and medicine·2026
Same journal

Fluvastatin-loaded chitosan-coated transfersomes for tumor-targeted nanotheranostics: Optimization, in-vitro cytotoxicity, and in-vivo radiokinetic evaluation.

Nanomedicine : nanotechnology, biology, and medicine·2026
Same journal

Nanostructured lipid carriers of lutein-based dissolving microneedle patch: A promising approach for the management of rheumatoid arthritis.

Nanomedicine : nanotechnology, biology, and medicine·2026
Same journal

Surface-charge-engineered magnetic silk fibroin nanocarriers for pH-responsive 5-fluorouracil delivery and in vitro magnetic localization.

Nanomedicine : nanotechnology, biology, and medicine·2026
See all related articles

Related Experiment Video

Updated: May 26, 2026

Using Polystyrene-block-poly(acrylic acid)-coated Metal Nanoparticles as Monomers for Their Homo- and Co-polymerization
09:02

Using Polystyrene-block-poly(acrylic acid)-coated Metal Nanoparticles as Monomers for Their Homo- and Co-polymerization

Published on: July 9, 2015

Polystyrene nanoparticles affecting blood coagulation.

Cecilia Oslakovic1, Tommy Cedervall, Sara Linse

  • 1Division of Clinical Chemistry, Department of Laboratory Medicine, Lund University, Skåne University Hospital, Malmö, Sweden.

Nanomedicine : Nanotechnology, Biology, and Medicine
|December 27, 2011
PubMed
Summary
This summary is machine-generated.

Polystyrene nanoparticles (NPs) impact blood clotting by altering thrombin generation. Amine-modified NPs reduce thrombin, while carboxyl-modified NPs activate coagulation pathways, influencing hemostasis.

More Related Videos

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

Related Experiment Videos

Last Updated: May 26, 2026

Using Polystyrene-block-poly(acrylic acid)-coated Metal Nanoparticles as Monomers for Their Homo- and Co-polymerization
09:02

Using Polystyrene-block-poly(acrylic acid)-coated Metal Nanoparticles as Monomers for Their Homo- and Co-polymerization

Published on: July 9, 2015

Microfluidics in Assessing Platelet Function
06:47

Microfluidics in Assessing Platelet Function

Published on: November 8, 2024

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles
10:12

Flash NanoPrecipitation for the Encapsulation of Hydrophobic and Hydrophilic Compounds in Polymeric Nanoparticles

Published on: January 7, 2019

Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Hematology

Background:

  • Nanoparticle (NP) interactions with biological systems are complex.
  • Blood coagulation involves intricate pro- and anticoagulant pathways.
  • Understanding NP effects on hemostasis is crucial for safety and therapeutic applications.

Purpose of the Study:

  • To investigate the effect of polystyrene nanoparticles (NPs) on thrombin generation in human plasma.
  • To elucidate the distinct roles of amine-modified and carboxyl-modified NPs in blood coagulation.

Main Methods:

  • Incubation of human plasma with amine-modified and carboxyl-modified polystyrene NPs.
  • Measurement of thrombin generation.
  • Analysis of coagulation factor binding to NPs.

Main Results:

  • Amine-modified NPs decreased thrombin formation by binding and depleting coagulation factors VII and IX.
  • Carboxyl-modified NPs served as a surface for activating the intrinsic pathway of blood coagulation.
  • Nanoparticle surface chemistry significantly alters blood coagulation dynamics.

Conclusions:

  • Polystyrene NPs differentially modulate blood coagulation.
  • Surface modification of NPs dictates their pro- or anticoagulant effects.
  • Nanoparticle-protein interactions profoundly influence hemostatic balance.