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Preparation and Characterization of Nanoliposomes for the Entrapment of Bioactive Hydrophilic Globular Proteins

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Published on: August 31, 2019

Physicochemical characterization of curcuminoid-loaded solid lipid nanoparticles.

Andreas Noack¹, Gerd Hause, Karsten Mäder

¹Insitute of Pharmacy, Martin Luther University Halle-Wittenberg, Wolfgang-Langenbeck-Straße 4, 06120 Halle, Saale, Germany.

International Journal of Pharmaceutics

|December 27, 2011

Summary

Solid lipid nanoparticles (SLN) loaded with curcuminoids were created using melt-homogenization. The drug was found to be on the surface of crystalline particles, influenced by the lipid matrix and aqueous environment.

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Preparation and Characterization of Individual and Multi-drug Loaded Physically Entrapped Polymeric Micelles

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Published on: August 28, 2015

Area of Science:

Materials Science
Pharmaceutical Nanotechnology
Physical Chemistry

Background:

Solid lipid nanoparticles (SLN) are a promising drug delivery system.
Curcuminoids are potent therapeutic agents with poor bioavailability.
Understanding drug-lipid interactions within SLN is crucial for optimizing delivery.

Purpose of the Study:

To produce curcuminoid-loaded solid lipid nanoparticles (SLN) using melt-homogenization.
To investigate the physical state and location of curcuminoids within different lipid matrices (medium chain triglycerides, trimyristin, tristearin).
To characterize the interactions between curcuminoids and lipid matrices in the nanoparticle formulation.

Main Methods:

Melt-homogenization technique for SLN production.
Differential scanning calorimetry (DSC) and 1H NMR for lipid matrix characterization.
Raman spectroscopy, fluorescence spectroscopy, and fluorescence anisotropy for curcuminoid state and location analysis.

Main Results:

Curcuminoid-loaded trimyristin SLN remained in a supercooled state.
Tristearin-based SLN exhibited polymorphic transitions (α- to β-phase).
Curcuminoids were found to be in an amorphous state, primarily on the surface of crystalline particles, and influenced by the lipid matrix and aqueous environment.

Conclusions:

The lipid matrix significantly influences the physical state and behavior of curcuminoids within SLN.
Curcuminoids are not secluded within the lipid matrix but interact with both the matrix and the external environment.
The surface location of curcuminoids on crystalline SLN suggests potential for modified release profiles.