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Updated: May 26, 2026
06:22
Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
Published on: April 7, 2021
Preventing the acute respiratory distress syndrome
Jonathan J D Repine1, Katrina M Crader, Nancy D Elkins
1Webb-Waring Center, University of Colorado Denver, V20, Mail Stop C322, 12850 East Montview Blvd., Aurora, CO 80045, USA. jonathan.repine@ucdenver.edu
Preventive Medicine
|December 27, 2011
Summary
Preventing Acute Respiratory Distress Syndrome (ARDS) is crucial due to its high mortality. Future prevention strategies will likely rely on real-time biomarker panels for early detection in at-risk patients.
Area of Science:
- Critical care medicine
- Pulmonology
- Biomarker research
Background:
- Supportive care for Acute Respiratory Distress Syndrome (ARDS) has improved.
- No pharmacological treatments effectively reduce established ARDS mortality.
- ARDS remains a significant cause of death in critically ill patients.
Purpose of the Study:
- To discuss challenges in preventing ARDS in at-risk individuals.
- To highlight the potential role of real-time biomarker panels in ARDS prevention.
- To address the unmet need for interventions in established ARDS.
Main Methods:
- Review of current supportive care strategies for ARDS.
- Discussion of limitations in pharmacological interventions for ARDS.
- Exploration of biomarker-based approaches for ARDS prediction.
Main Results:
- Current supportive measures do not reduce ARDS mortality.
- Pharmacological interventions for established ARDS are lacking.
- Biomarker panels are essential for real-time ARDS prevention.
Conclusions:
- Effective prevention of ARDS is a critical unmet need.
- Real-time biomarker panels are likely key to future ARDS prevention strategies.
- Further research into predictive biomarkers for ARDS is warranted.
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