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Pituitary hormones in brain: where, how, and why?
Science (New York, N.Y.)
|July 27, 1979
Summary
Peptide hormones, typically from the pituitary gland, are found in the central nervous system and influence behavior. These hormones may be synthesized within the brain, suggesting unique regulatory roles.
Area of Science:
- Neuroendocrinology
- Neuroscience
- Molecular Biology
Background:
- Peptide and protein hormones are traditionally associated with the pituitary gland.
- Their presence and function within the central nervous system (CNS) are increasingly recognized.
Purpose of the Study:
- To investigate the presence and potential function of pituitary-origin hormones within the CNS.
- To explore the synthesis and regulation of these hormones in the brain.
Main Methods:
- Radioimmunoassay (RIA) was used to detect hormone levels.
- Bioassays were employed to assess functional activity.
- Immunocytochemical techniques visualized hormone localization within neural tissues.
Main Results:
- Peptide and protein hormones were detected in the central nervous system.
- Intracerebral administration of these hormones induced behavioral responses.
- Evidence suggests these hormones are synthesized within the CNS.
Conclusions:
- Hormones of pituitary origin have a significant presence and role within the central nervous system.
- These neurohormones may function as neurotransmitters or neuromodulators.
- Central nervous system synthesis and distinct regulatory mechanisms differentiate them from their pituitary counterparts.