Related Experiment Video

Updated: May 26, 2026

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries
08:49

Identification of Mediators of T-cell Receptor Signaling via the Screening of Chemical Inhibitor Libraries

Published on: January 22, 2019

Effects of SCR-3 on the immunosuppression accompanied with the systemic inflammatory response syndrome

Jun Li1, Jie Niu, Shan Ou

  • 1Department of Anesthesia, General Hospital of Chengdu Military Command Area, Chengdu 610083, Sichuan Province, People's Republic of China.

Molecular and Cellular Biochemistry
|December 27, 2011
PubMed

Insights

Steroid receptor coactivator-3 (SRC-3) deficiency severely impairs the innate immune system, hindering bacterial clearance. Absence of SRC-3 exacerbates immunosuppression during systemic inflammatory response syndrome (SIRS).

Area of Science:

  • Immunology
  • Molecular Biology
  • Cellular Biology

Background:

  • Steroid receptor coactivator-3 (SRC-3) is a key protein in mammary gland development and tumorigenesis.
  • Systemic inflammatory response syndrome (SIRS) is often accompanied by immunosuppression.
  • The role of SRC-3 in immune response during SIRS is not well understood.

Purpose of the Study:

  • To investigate the role of SRC-3 in the innate immune response during SIRS.
  • To determine the effect of SRC-3 deficiency on bacterial clearance and immune cell function.

Main Methods:

  • Utilized SRC-3 gene knockout mice.
  • Performed bacterial clearance assays using blood cultures and frozen sections.
  • Established an animal model of inflammatory reaction to assess immune function.
  • Analyzed lymphocyte subsets and T-cell immune function.

Main Results:

  • Absence of SRC-3 significantly damaged the innate immune system, decreasing bacterial inactivation and phagocytosis.
  • SRC-3 deficiency weakened phagocytes' ability to degrade bacteria and their metabolites.
  • SRC-3 plays a crucial role in maintaining T-cell immune function; its absence leads to severe T-cell immune disorder.
  • SIRS destroyed lymphocyte subset homeostasis, suppressing cellular immunity, an effect aggravated by SRC-3 absence.

Conclusions:

  • SRC-3 deficiency exacerbates immunosuppression during SIRS.
  • SRC-3 is a critical regulator of infection and inflammation.
  • SRC-3 protein is essential for the development of immunosuppression associated with SIRS.

Related Concept Videos

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents01:29

Drugs for Treatment of Crohn's Disease in IBD Using Immunomodulatory Agents

Crohn's disease is an inflammatory bowel disorder marked by chronic inflammation of the GI tract. Various treatment strategies for Crohn's disease are employed, such as immunomodulatory agents, glucocorticoids, and biologics or anti-TNF therapy. Azathioprine (Imuran), a commonly used immunomodulatory drug for Crohn's disease, is converted in the body to mercaptopurine, which inhibits purine biosynthesis and cell proliferation. Both are utilized in severe cases of Inflammatory Bowel Disease...
Inflammatory Bowel Disease III: Crohn's Disease01:25

Inflammatory Bowel Disease III: Crohn's Disease

Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
Immunodeficiency Diseases01:25

Immunodeficiency Diseases

Immunodeficiency disorders are conditions in which the immune system's ability to fight infectious disease and cancer is compromised or entirely absent. The immune system comprises a complex network of cells, tissues, and organs that work together to protect the body from potentially harmful invaders. When this system is deficient or not functioning properly, it leaves the body susceptible to infections, diseases, or other complications.
There are three main causes of immunodeficiency disorders...
Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF01:24

Drugs for Treatment of Crohn's Disease in IBD Using Biologic Agents: Anti-TNF

Tumor Necrosis Factor (TNF), a proinflammatory cytokine, contributes significantly to the inflammation seen in Crohn's disease. It exists as soluble TNF and membrane-bound TNF, with actions mediated through TNF receptors (TNFR). TNFR activation leads to the release of proinflammatory cytokines, T-cell activation, collagen production, and leukocyte migration, all contributing to inflammation in Crohn's disease. Anti-TNF monoclonal antibodies, namely infliximab (Remicade), adalimumab (Humira),...
Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids01:21

Drugs for Treatment of Crohn's Disease in IBD Using Glucocorticoids

Glucocorticoids, a class of anti-inflammatory drugs, are pivotal in treating moderate to severe Crohn's disease by inducing remission. They exhibit their anti-inflammatory action by inhibiting the production of inflammatory cytokines such as tumor necrosis factor (TNF)-α, interleukin (IL)-1, and chemokines like IL-8. In addition, they reduce the expression of inflammatory cell adhesion molecules and inhibit gene transcription of nitric oxide synthase, phospholipase A2, cyclooxygenase-2 (COX-2),...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...