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Related Concept Videos

Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...
Encephalitis ll: Pathophysiology01:26

Encephalitis ll: Pathophysiology

Encephalitis is inflammation of the brain parenchyma caused by direct viral invasion or immune-mediated mechanisms triggered by infections or tumors. Both processes lead to neuronal injury, disrupted neurotransmission, and diverse neurological symptoms, often with overlapping clinical and pathological features.Autoimmune EncephalitisIn autoimmune encephalitis, antibodies target neuronal antigens on cell surfaces, synapses, or within neurons. A key example is anti-NMDAR encephalitis, which can...
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Cystic Fibrosis: Pathogenesis

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Compartmentalized dynamics of cytomegalovirus replication in treated congenital infection.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology·2016
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Effects of donor/recipient human leukocyte antigen mismatch on human cytomegalovirus replication following liver transplantation.

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Human herpesvirus vaccines and future directions.

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Related Experiment Video

Updated: May 26, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
05:53

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

Cytomegalovirus: recent progress in understanding pathogenesis and control.

V C Emery1

  • 1Department of Infection (Royal Free Campus), University College London, Rowland Hill Street, Hampstead, London, NW3 2QG, UK. v.emery@ucl.ac.uk

QJM : Monthly Journal of the Association of Physicians
|December 27, 2011
PubMed
Summary

Human cytomegalovirus (HCMV) is a significant pathogen affecting neonates and transplant recipients, contributing to various diseases and early mortality in aging individuals. This review explores recent advancements in understanding HCMV-host interactions and novel therapeutic strategies.

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Related Experiment Videos

Last Updated: May 26, 2026

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates
05:53

Use of In vivo Imaging to Monitor the Progression of Experimental Mouse Cytomegalovirus Infection in Neonates

Published on: July 6, 2013

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus
11:28

Dissecting Host-virus Interaction in Lytic Replication of a Model Herpesvirus

Published on: October 7, 2011

Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain
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Intracerebroventricular and Intravascular Injection of Viral Particles and Fluorescent Microbeads into the Neonatal Brain

Published on: July 24, 2016

Area of Science:

  • Virology
  • Immunology
  • Infectious Diseases

Background:

  • Human cytomegalovirus (HCMV) poses a significant threat to vulnerable populations, including neonates and organ transplant recipients.
  • HCMV infection is linked to diverse pathologies, such as inflammatory conditions and increased mortality in aging demographics.

Purpose of the Study:

  • To review recent breakthroughs in understanding the intricate interactions between HCMV and its host.
  • To discuss emerging therapeutic strategies for controlling HCMV infections.

Main Methods:

  • This review synthesizes current research on HCMV pathogenesis and host responses.
  • It analyzes novel antiviral therapies and immunomodulatory approaches.

Main Results:

  • Advances in understanding HCMV virus-host interactions provide new targets for therapeutic intervention.
  • Several promising therapeutic control measures are under investigation.

Conclusions:

  • A deeper comprehension of HCMV biology is crucial for developing effective treatments.
  • New therapeutic options hold promise for mitigating the impact of HCMV in at-risk patient groups.