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Updated: May 26, 2026
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Optimized Management of Endovascular Treatment for Acute Ischemic Stroke
Published on: January 18, 2018
Continuous positive airway pressure ventilation for acute ischemic stroke: a randomized feasibility study
Jens Minnerup1, Martin Andreas Ritter, Heike Wersching
1Department of Neurology, University of Münster, Albert-Schweitzer-Straße 33, 48149 Münster, Germany. minnerup@uni-muenster.de
Stroke
|December 27, 2011
Summary
Continuous positive airway pressure (CPAP) treatment initiated on the first night after stroke is feasible. Early CPAP use in stroke patients showed promising trends in neurological recovery without causing harm.
Area of Science:
- Neurology
- Sleep Medicine
- Critical Care Medicine
Background:
- Sleep-related breathing disorders are common post-stroke.
- Early intervention strategies are crucial for stroke recovery.
Purpose of the Study:
- To assess the feasibility of initiating continuous positive airway pressure (CPAP) treatment on the first night after stroke.
- To evaluate the impact of early CPAP on apnea-hypopnea index, nursing workload, and CPAP adherence.
Main Methods:
- An open-label, parallel-group trial involving 50 stroke patients randomly assigned to CPAP therapy or a control group.
- Polysomnography was conducted on the fourth night post-stroke.
- Intervention group received CPAP starting the first night, with adjustments based on apnea-hypopnea index.
Main Results:
- CPAP significantly reduced the apnea-hypopnea index (32.2±25.3 to 9.8±6.6, P=0.0001).
- Nursing workload did not differ significantly between groups (P=0.741).
- A trend towards greater NIH Stroke Scale improvement was observed in the CPAP group (P=0.092), with significant improvement in those with excellent CPAP use (P=0.022).
Conclusions:
- Initiating CPAP therapy on the first night post-stroke appears feasible.
- Early CPAP treatment was not associated with neurological deterioration.
- Excellent CPAP adherence correlated with improved neurological outcomes.
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