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Related Concept Videos

Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Desmosomes01:05

Desmosomes

The term desmosome derives from the Greek words "desmo" and "soma" meaning "adhesion bodies." This structure was first observed during the late 1800s and described as small, dense nodules in the epidermis. Desmosomes are button-like structures that help form an interlinked network of intermediate filaments across the cells. These junctions are  essential to hold cells together under mechanical stress and to maintain tissue integrity. Desmosomes are multi-protein complexes comprising desmosomal...
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...

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Dermoscopy Aids in the Diagnosis of Discoid Lupus Erythematosus
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Unilateral linear punctate palmoplantar keratoderma.

Sudhanshu Sharma1, Krishna Deb Barman, Vijay Kumar Garg

  • 1Department of Dermatology and Venereology, Maulana Azad Medical College and Associated Hospital, New Delhi, India.

Indian Journal of Dermatology, Venereology and Leprology
|December 27, 2011
PubMed
Summary

A rare linear variant of punctate palmoplantar keratoderma, a condition causing skin thickening on palms and soles, was observed unilaterally in a child. This unique presentation has not been previously documented in medical literature.

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Area of Science:

  • Dermatology
  • Medical Genetics

Background:

  • Punctate palmoplantar keratoderma (PPKP), also known as Brauer-Buschke-Fischer syndrome, is a rare condition characterized by small, pinpoint thickenings on the palms and soles.
  • Linear presentations of PPKP are exceptionally rare, with limited data on their incidence.
  • Unilateral involvement of linear punctate palmoplantar keratoderma has not been previously reported in scientific literature.

Purpose of the Study:

  • To report the first documented case of unilateral linear punctate palmoplantar keratoderma.
  • To describe the clinical and histological features of this rare dermatological condition in a pediatric patient.

Main Methods:

  • Case report of a 12-year-old child.
  • Clinical examination of the affected areas (left sole and hand).
  • Histopathological analysis of the skin lesion.

Main Results:

  • The patient presented with an asymptomatic linear plaque exhibiting punctate keratoderma on the left sole and hand.
  • Histology showed hyperkeratotic epidermis.
  • Key features of other keratodermas, such as columns of parakeratosis or a cornified lamella, were absent.

Conclusions:

  • This case represents the first report of unilateral linear punctate palmoplantar keratoderma.
  • The findings expand the known spectrum of punctate palmoplantar keratoderma presentations.
  • Histological examination is crucial for differentiating this rare variant from other palmoplantar keratodermas.