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Acute hemorrhagic edema of infancy: a report of two cases

Atul Dongre1, Vijay Adhe, Dimple Kothari

  • 1Department of Skin and VD, Seth GS Medical College and KEM Hospital, Mumbai, Maharashtra, India. atul507@yahoo.co.in

Indian Journal of Dermatology, Venereology and Leprology
|December 27, 2011
PubMed

Insights

Acute hemorrhagic edema of infancy, a form of childhood leukocytoclastic vasculitis, typically presents after an upper respiratory infection. This condition follows a benign course, with lesions resolving completely without lasting effects in affected children.

Area of Science:

  • Pediatric dermatology
  • Pediatric rheumatology
  • Pediatric pathology

Background:

  • Acute hemorrhagic edema of infancy (AHEI) is a rare, self-limiting vasculitic condition.
  • It is considered a clinical variant of childhood leukocytoclastic vasculitis.
  • AHEI typically affects infants and young children.

Purpose of the Study:

  • To describe the clinical presentation and histopathological findings of AHEI.
  • To highlight the benign and self-resolving nature of this vasculitic condition in children.
  • To report on two pediatric cases of AHEI.

Main Methods:

  • Case report of two pediatric patients.
  • Clinical examination including assessment of skin lesions and limb swelling.
  • Histopathological examination of skin biopsy specimens to confirm leukocytoclastic vasculitis.

Main Results:

  • Both patients presented with symptoms following an upper respiratory tract infection.
  • Clinical manifestations included limb swelling and purpuric/ecchymotic skin lesions.
  • Skin biopsies confirmed leukocytoclastic vasculitis in both cases.

Conclusions:

  • Acute hemorrhagic edema of infancy is a benign leukocytoclastic vasculitis in children.
  • The condition typically resolves completely without sequelae.
  • Prompt diagnosis and supportive care are important for managing AHEI.

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