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Related Experiment Video

Updated: May 26, 2026

A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells
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A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells

Published on: January 22, 2021

Differential CD133 expression pattern during mouse colon tumorigenesis.

Vincenzo Arena1, Emanuele Caredda, Valerio Cufino

  • 1Institute of Pathology, Università Cattolica del Sacro Cuore, Rome, Italy.

Anticancer Research
|December 27, 2011
PubMed
Summary
This summary is machine-generated.

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CD133 expression increases in early colon tumorigenesis. CD133-expressing cells are crucial throughout colon cancer development, from initial stages to advanced disease.

Area of Science:

  • Oncology
  • Cell Biology
  • Gastroenterology

Background:

  • The cancer stem cell (CSC) model posits that CSCs drive tumor initiation.
  • CD133 is a cell surface marker associated with CSCs in various carcinomas.
  • The specific role of CD133 in colon cancer development is not fully understood.

Purpose of the Study:

  • To investigate the role of CD133 in colon tumorigenesis.
  • To evaluate CD133 expression during the progression of colon cancer in a mouse model.

Main Methods:

  • Immunohistochemistry was used to detect CD133.
  • A mouse model of colitis-related colon tumorigenesis was employed.
  • The model involved combined treatment with azoxymethane (AOM) and dextran sodium sulfate (DSS).

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Last Updated: May 26, 2026

A Three-dimensional Model of Spheroids to Study Colon Cancer Stem Cells
06:38

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Published on: January 22, 2021

In vitro Organoid Culture of Primary Mouse Colon Tumors
07:33

In vitro Organoid Culture of Primary Mouse Colon Tumors

Published on: May 17, 2013

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer
06:01

A Genetically Engineered Mouse Model of Sporadic Colorectal Cancer

Published on: July 6, 2017

Main Results:

  • CD133 was found in rare cells at the bottom of crypts in normal colon tissue.
  • CD133-positive cells significantly increased in dysplastic lesions.
  • Expression decreased from dysplasia to adenoma and cancer but remained higher than in normal tissue.

Conclusions:

  • Increased CD133 expression is observed in the early stages of mouse colon tumorigenesis.
  • CD133-expressing cells likely play a significant role throughout the entire process of colon cancer development.