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Updated: May 26, 2026

Quantitative PCR-based Assay to Measure Sonic Hedgehog Signaling in Cellular Model of Ciliogenesis
Published on: January 31, 2025
Design, synthesis, and biological evaluation of estrone-derived hedgehog signaling inhibitors
Jeffrey D Winkler1, André K Isaacs, Chaomei Xiang
1Department of Chemistry, University of Pennsylvania, Philadelphia, PA 19104, USA.
Abstract:
The design, synthesis and biological evaluation of new analogs of the naturally occurring compound cyclopamine, a Hedgehog signaling inhibitor, are described. Stucture-activity relationship studies lead to an evolving model for the pharmacophore of this medically promising compound class of anti-cancer chemotherapeutic agents.
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