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Updated: May 26, 2026

A Two-Step Protocol for Umpolung Functionalization of Ketones Via Enolonium Species
Published on: August 16, 2018
2-[(Pyrimidin-2-yl-amino)-meth-yl]phenol
Structural analysis of a novel compound C(11)H(11)N(3)O reveals twisted aromatic rings and specific hydrogen bonding interactions. These findings offer insights into molecular conformation and intermolecular forces in crystalline structures.
Area of Science:
- Crystallography
- Organic Chemistry
- Supramolecular Chemistry
Background:
- Understanding molecular interactions is crucial in chemistry.
- Crystal structure analysis provides detailed insights into molecular arrangements and bonding.
Purpose of the Study:
- To elucidate the crystal structure and intermolecular interactions of the compound C(11)H(11)N(3)O.
- To investigate the role of hydrogen bonding in the compound's solid-state structure.
Main Methods:
- Single-crystal X-ray diffraction was employed to determine the molecular and crystal structure.
- Analysis of hydrogen bonding networks and torsional angles was performed.
Main Results:
- The crystal structure of C(11)H(11)N(3)O was determined.
- A significant twist of 72.58(8)° was observed between the aromatic rings linked by a -CH(2)-NH- group.
- Intramolecular hydrogen bonding was identified, with the hydroxy group acting as a donor to a pyrimidine nitrogen atom.
- Intermolecular hydrogen bonding was observed, involving the other pyrimidine nitrogen atom as an acceptor.
Conclusions:
- The study successfully characterized the C(11)H(11)N(3)O crystal structure.
- The observed conformational twist and hydrogen bonding patterns dictate the compound's solid-state architecture.
- These interactions are key to understanding the compound's physical and chemical properties.
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