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Atypical extraventricular neurocytoma.

Hyunho Choi1, Sung-Hye Park, Dong Gyu Kim

  • 1Department of Neurosurgery, Cancer Research Institute, Ischemic/Hypoxic Disease Institute, Seoul National University College of Medicine, Seoul, Korea.

Journal of Korean Neurosurgical Society
|December 27, 2011
PubMed
Summary

Extraventricular neurocytoma (EVN) can transform into an atypical form over 15 years, initially misdiagnosed as oligodendroglioma. This case highlights the importance of considering EVN in differential diagnoses for similar brain tumors.

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Area of Science:

  • Neuro-oncology
  • Pediatric Neurosurgery
  • Pathology

Background:

  • Extraventricular neurocytoma (EVN) is a rare tumor, often challenging to diagnose.
  • Distinguishing EVN from other glial tumors like oligodendroglioma is critical for appropriate treatment and prognosis.

Observation:

  • A case is presented of a child initially diagnosed with oligodendroglioma at age 8.
  • The tumor recurred 15 years later, and the recurrent mass was diagnosed as atypical EVN.
  • Review of the initial specimen with immunohistochemistry confirmed the original diagnosis as EVN.

Findings:

  • The study identified a rare case of EVN transforming into an atypical EVN over a 15-year period.
  • Immunohistochemistry, specifically synaptophysin staining, was crucial in revising the initial diagnosis.
Keywords:
Atypical extraventricular neurocytomaDifferential diagnosisOligodendrogliomaRecurrence

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  • The patient achieved long-term stability after surgical resection and gamma knife treatment.
  • Implications:

    • This case underscores the necessity of including EVN in the differential diagnosis for tumors initially presenting as oligodendroglioma.
    • Long-term follow-up and careful pathological review are essential for accurate diagnosis and management of rare neuro-oncological entities.
    • Understanding the potential for tumor transformation in EVN can inform future treatment strategies and prognostic assessments.