[Ectericide as a dispersion medium for the preparation of prospective clinical liposomal drug forms]

The possibility of using ectericide, having antibacterial, detergent, antioxidative, and reparative effects, as a dispersion medium for liposome production has been studied. Its application allows for elaboration of a simplified liposome production technique simultaneously imparting them stability against oxidation, heating, and pH changes. A technology to produce multivesicular liposomes with ectericide++, containing rifampicin in the membranous envelope and gentamicin in the inner volume, has been developed. Liposomal antibiotics proved to be effective in clinical trials.