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Detection of Aggregation-Prone Behavior in Mutant P53 V157F Breast Cancer Cells Using Multipoint Thioflavin T Fluorescence

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p53 codon 72 polymorphism as a progression index for bladder cancer.

Hung-Yu Lin¹, Chun-Hsiung Huang, Tsan-Jung Yu

¹Department of Urology, E-DA Hospital/I-SHOU University, Kaohsiung, Taiwan, ROC.

Oncology Reports

|December 28, 2011

Summary

The p53 codon 72 Pro/Pro genotype is linked to bladder cancer progression, not initial development. This genotype shows a high negative predictive value (NPV) for invasive tumors, suggesting its clinical utility as a bladder cancer progression index.

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Area of Science:

Genetics and Oncology
Molecular Biology
Cancer Biomarkers

Background:

The p53 codon 72 polymorphism is a common genetic variation.
Its role in bladder cancer incidence and progression requires further elucidation.
Accurate bladder cancer management indices are crucial for patient outcomes.

Purpose of the Study:

To evaluate the positive predictive value (PPV) and negative predictive value (NPV) of p53 codon 72 genotypes.
To determine if p53 codon 72 can serve as a bladder cancer management index.
To assess the association of p53 codon 72 polymorphism with bladder cancer incidence, grade, invasiveness, recurrence, and survival.

Main Methods:

Case-control study including 96 bladder cancer patients and 569 controls.
Logistic regression analysis adjusted for age and gender.
Cox regression analysis for tumor recurrence and cancer-related death.

Main Results:

The Pro/Pro genotype was not significantly associated with bladder cancer incidence.
Pro/Pro genotype strongly correlated with muscle-invasive tumors (P=0.002), with a 3.36-fold increased risk.
The Pro/Pro genotype demonstrated a high NPV (88.00%) for invasive tumors and was associated with cancer-related death (OR=2.87).

Conclusions:

p53 codon 72 polymorphism influences bladder cancer progression, not incidence or prognosis.
The Pro/Pro genotype exhibits a high NPV for bladder cancer progression.
The Pro/Pro genotype can be clinically utilized as a progression index in bladder cancer management.