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Related Concept Videos

Endoscopic Procedures II: Colonoscopy01:25

Endoscopic Procedures II: Colonoscopy

The colon, or large intestine, is the final segment of the digestive system. Its primary functions include absorbing water and vitamins produced by gut bacteria and transforming waste from liquid to solid to form stool. In adults, the large intestine is approximately 5 feet long and consists of four main sections:
Diverticular Disease of the Colon01:27

Diverticular Disease of the Colon

Diverticular disease involves the formation of diverticula—small sac-like outpouchings of the colonic wall—and their complications. It most commonly affects the sigmoid colon due to higher intraluminal pressure and structural vulnerability. It results from structural weakness and increased pressure in the colon, producing pseudodiverticula that may remain silent or progress to inflammation and serious complications.Structure of DiverticulaIn diverticulosis, these outpouchings are...
Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy01:26

Imaging Studies III: Gastrointestinal Motility Studies and Virtual Colonoscopy

This lesson explores three gastrointestinal imaging techniques: radionuclide testing, colonic transit studies, and virtual colonoscopy.
Radionuclide Testing
Radionuclide testing is a sophisticated medical technique for assessing gastrointestinal motility. It focuses on gastric emptying and colonic transit time. Radioactive markers track the movement of food through the digestive system, providing insights into gastrointestinal disorders.
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Inflammatory Bowel Disease II: Ulcerative Colitis01:20

Inflammatory Bowel Disease II: Ulcerative Colitis

Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal BarrierA...

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Related Experiment Video

Updated: May 26, 2026

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
07:35

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

Interval cancers after negative colonoscopy: population-based case-control study.

Hermann Brenner1, Jenny Chang-Claude, Christoph M Seiler

  • 1Division of Clinical Epidemiology and Ageing Research, German Cancer Research Center, Heidelberg, Germany. h.brenner@dkfz.de

Gut
|December 28, 2011
PubMed
Summary
This summary is machine-generated.

Interval colorectal cancers are more common in women and in the right colon. Improving colonoscopy completeness, especially for positive fecal occult blood tests, could prevent many interval cancers.

Related Experiment Videos

Last Updated: May 26, 2026

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection
07:35

Evaluation of Colorectal Cancer Risk and Prevalence by Stool DNA Integrity Detection

Published on: June 8, 2020

Area of Science:

  • Gastroenterology
  • Oncology
  • Preventive Medicine

Background:

  • Colorectal cancer (CRC) risk after a negative colonoscopy is low, but interval cancers do occur.
  • Understanding the characteristics and predictors of these interval cancers is crucial for improving CRC detection rates.

Purpose of the Study:

  • To assess the characteristics and predictors of interval colorectal cancers following a negative colonoscopy.
  • To identify factors associated with interval cancers to enhance colonoscopy performance and preventability.

Main Methods:

  • A population-based case-control study in Southern Germany (2003-7).
  • Compared sociodemographic and tumor characteristics of 78 interval cancer patients with 433 screening-detected CRC cases.
  • Assessed preceding negative colonoscopy indications and completeness against 515 controls.

Main Results:

  • Interval cancers were more frequent in women (56.4%) and in the caecum/ascending colon (OR 1.98).
  • Incomplete preceding colonoscopies (caecum not reached) were more common in interval cancer cases (18.1%).
  • Positive fecal occult blood test follow-up (men: OR 5.49) and incompleteness (women: OR 4.38) were strong predictors.

Conclusions:

  • A significant portion of interval colorectal cancers may result from missed neoplasms during colonoscopy.
  • Enhanced colonoscopy performance, particularly in specific patient groups and indications, could significantly reduce interval cancer rates.