Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation01:24

One-Compartment Open Model: Wagner-Nelson and Loo Riegelman Method for ka Estimation

This lesson introduces two critical methods in pharmacokinetics, the Wagner-Nelson and Loo-Riegelman methods, used for estimating the absorption rate constant (ka) for drugs administered via non-intravenous routes. The Wagner-Nelson method relates ka to the plasma concentration derived from the slope of a semilog percent unabsorbed time plot. However, it is limited to drugs with one-compartment kinetics and can be impacted by factors like gastrointestinal motility or enzymatic degradation.
On...
Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model01:13

Parameters Affecting Nonlinear Elimination: Zero-Order Input, First-Order Absorption and Two-Compartment Model

Drugs administered through various routes can lead to nonlinear elimination, resulting in complex pharmacokinetic behaviors crucial to understanding efficacious drug dosing.
When a drug is administered through a constant intravenous infusion and eliminated via nonlinear pharmacokinetics, it follows zero-order input. For example, oral drugs undergo first-order absorption upon administration and are eliminated through nonlinear pharmacokinetics.
In the case of subcutaneously administered drugs,...
Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving01:29

Mechanistic Models: Compartment Models in Algorithms for Numerical Problem Solving

Mechanistic models play a crucial role in algorithms for numerical problem-solving, particularly in nonlinear mixed effects modeling (NMEM). These models aim to minimize specific objective functions by evaluating various parameter estimates, leading to the development of systematic algorithms. In some cases, linearization techniques approximate the model using linear equations.
In individual population analyses, different algorithms are employed, such as Cauchy's method, which uses a...
Model Approaches for Pharmacokinetic Data: Distributed Parameter Models01:06

Model Approaches for Pharmacokinetic Data: Distributed Parameter Models

Pharmacokinetic models are mathematical constructs that represent and predict the time course of drug concentrations in the body, providing meaningful pharmacokinetic parameters. These models are categorized into compartment, physiological, and distributed parameter models.
The distributed parameter models are specifically designed to account for variations and differences in some drug classes. This model is particularly useful for assessing regional concentrations of anticancer or...
Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis00:59

Model-Independent Approaches for Pharmacokinetic Data: Noncompartmental Analysis

Noncompartmental analyses offer an alternative method for describing drug pharmacokinetics without relying on a specific compartmental model. In this approach, the drug's pharmacokinetics are assumed to be linear, with the terminal phase log-linear. This assumption allows for simplified analysis and interpretation of the drug's behavior in the body.
One important characteristic of noncompartmental analyses is that drug exposure increases proportionally with increasing doses. This relationship...
Vector Algebra: Method of Components01:08

Vector Algebra: Method of Components

It is cumbersome to find the magnitudes of vectors using the parallelogram rule or using the graphical method to perform mathematical operations like addition, subtraction, and multiplication. There are two ways to circumvent this algebraic complexity. One way is to draw the vectors to scale, as in navigation, and read approximate vector lengths and angles (directions) from the graphs. The other way is to use the method of components.
In many applications, the magnitudes and directions of...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Indoor Scene Recognition Mechanism Based on Direction-Driven Convolutional Neural Networks.

Sensors (Basel, Switzerland)·2023
Same author

A comparative study of semantic segmentation of omnidirectional images from a motorcycle perspective.

Scientific reports·2022
Same author

An Evidential Framework for Localization of Sensors in Indoor Environments.

Sensors (Basel, Switzerland)·2020
Same author

Hyperspectral Unmixing in Presence of Endmember Variability, Nonlinearity, or Mismodeling Effects.

IEEE transactions on image processing : a publication of the IEEE Signal Processing Society·2016
Same author

Nonlinear feature extraction using kernel principal component analysis with non-negative pre-image.

Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2010

Related Experiment Video

Updated: May 26, 2026

O-cresol Concentration Online Measurement Based On Near Infrared Spectroscopy Via Partial Least Square Regression
06:50

O-cresol Concentration Online Measurement Based On Near Infrared Spectroscopy Via Partial Least Square Regression

Published on: November 8, 2019

Online kernel principal component analysis: a reduced-order model.

Paul Honeine1

  • 1Laboratoire de Modélisation et Sûreté des Systèmes, Institut Charles Delaunay (UMR CNRS 6279), Universitè de Technologie de Troyes, 12 rue Marie Curie, BP 2060, 10010 Troyes cedex, France. paul.honeine@utt.fr

IEEE Transactions on Pattern Analysis and Machine Intelligence
|December 28, 2011
PubMed
Summary

This study introduces an online algorithm for kernel principal component analysis (kernel-PCA), a nonlinear dimensionality reduction technique. The novel approach effectively reduces model order for efficient data analysis, outperforming existing methods on synthetic and image datasets.

More Related Videos

Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms
08:51

Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms

Published on: November 1, 2019

Related Experiment Videos

Last Updated: May 26, 2026

O-cresol Concentration Online Measurement Based On Near Infrared Spectroscopy Via Partial Least Square Regression
06:50

O-cresol Concentration Online Measurement Based On Near Infrared Spectroscopy Via Partial Least Square Regression

Published on: November 8, 2019

Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms
08:51

Statistical Modelling of Cortical Connectivity Using Non-invasive Electroencephalograms

Published on: November 1, 2019

Area of Science:

  • Machine Learning
  • Data Science
  • Dimensionality Reduction

Background:

  • Kernel principal component analysis (kernel-PCA) is a powerful nonlinear extension of principal component analysis.
  • Traditional kernel-PCA often requires a model order equal to the number of observations, limiting its online application.
  • Efficient dimensionality reduction is crucial for analyzing large and complex datasets.

Purpose of the Study:

  • To propose a novel online algorithm for kernel-PCA.
  • To address the challenge of high model order in kernel-based methods for online processing.
  • To develop a computationally efficient approach for nonlinear dimensionality reduction.

Main Methods:

  • Developed a kernel-based version of Oja's rule for online kernel-PCA.
  • Introduced a model order control mechanism for the online algorithm.
  • Derived a recursive algorithm to extract multiple principal axes.
  • Analyzed theoretical error bounds for the reduced-order model.

Main Results:

  • The proposed online algorithm effectively performs kernel-PCA with controlled model order.
  • Theoretical analysis provides an upper bound on approximation errors.
  • Experimental validation on synthetic and handwritten digit datasets demonstrates effectiveness.
  • The algorithm shows competitive or superior performance compared to classical and iterative kernel-PCA.

Conclusions:

  • The developed online kernel-PCA algorithm offers an efficient and effective solution for nonlinear dimensionality reduction.
  • Controlling model order is key to enabling online applications of kernel-PCA.
  • The approach is suitable for real-world applications, including image analysis.