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Related Experiment Video

Updated: May 26, 2026

Isolation, Purification, and Differentiation of Osteoclast Precursors from Rat Bone Marrow

Isolation, Purification, and Differentiation of Osteoclast Precursors from Rat Bone Marrow

Published on: May 19, 2019

[Odontoclasts and calcitonin].

Koji Okabe¹, Fujio Okamoto, Hiroshi Kajiya

¹Department of Physiological Science and Molecular Biology, Fukuoka Dental College, Japan.

Clinical Calcium

|December 28, 2011

Summary

Odontoclasts, involved in deciduous tooth root resorption, may differ from osteoclasts. This study investigates calcitonin receptor presence and function in human odontoclasts, impacting root resorption understanding.

Area of Science:

Cell Biology
Endocrinology
Dental Research

Context:

Odontoclasts resorb deciduous tooth roots, sharing similarities with osteoclasts but with distinct regulatory mechanisms.
Calcitonin receptor is a key osteoclast marker, and calcitonin inhibits bone resorption.
The presence and role of calcitonin receptors in human odontoclasts remain debated.

Purpose:

To investigate the physiological properties and differentiation of odontoclasts.
To examine the effects of calcitonin on root resorption.
To clarify the presence and function of calcitonin receptors in human odontoclasts and periodontal ligament cells.

Summary:

This research reviews odontoclast physiology and differentiation, focusing on calcitonin's effects on root resorption.

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A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

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Last Updated: May 26, 2026

Isolation, Purification, and Differentiation of Osteoclast Precursors from Rat Bone Marrow

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Using Inducible Osteoblastic Lineage-Specific Stat3 Knockout Mice to Study Alveolar Bone Remodeling During Orthodontic Tooth Movement

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A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

A Simple Pit Assay Protocol to Visualize and Quantify Osteoclastic Resorption In Vitro

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It presents new findings on human odontoclasts and periodontal ligament cells from deciduous tooth roots.

The study addresses the controversial role of calcitonin receptors in human odontoclasts.

Impact:

Provides crucial insights into the distinct mechanisms of root resorption compared to bone resorption.
Clarifies the controversial role of calcitonin receptors in human odontoclasts.
Contributes to understanding the regulation of deciduous tooth exfoliation and potential therapeutic targets.