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Related Experiment Video

Updated: May 26, 2026

Studying Orthodontic Tooth Movement in Mice

Studying Orthodontic Tooth Movement in Mice

Published on: August 2, 2024

[Tooth and bone research using genetically modified mice].

¹Department of Human Development and Fostering, Meikai University School of Dentistry, Saitama, Japan.

Clinical Calcium

|December 28, 2011

Summary

Tooth and bone share hydroxyapatite composition. Mouse studies reveal molecules crucial for tooth development and eruption, aiding understanding of genetic disorders affecting tooth number and structure.

Area of Science:

Biomineralization and developmental biology.
Focus on hard tissue formation and cellular interactions.

Context:

Tooth and bone share hydroxyapatite composition, but differ in their developmental and environmental exposure.
Tooth development involves oral epithelium invagination and ectomesenchymal cell aggregation.
Tooth eruption is a unique process involving pathway formation and vertical movement into the oral cavity.

Purpose:

To review molecular mechanisms underlying tooth development and eruption.
To discuss findings from mouse studies on tooth development and eruption.
To explore genetic underpinnings of human disorders with abnormal tooth characteristics.

Summary:

This review examines the molecular mechanisms of tooth development and eruption, drawing insights from mouse models.

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Last Updated: May 26, 2026

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Published on: April 26, 2024

It highlights the shared hydroxyapatite composition of teeth and bone, contrasting their developmental pathways and eruption processes.

Abnormalities in tooth number and structure, linked to genetic disorders, are discussed in relation to identified developmental molecules.

Impact:

Enhances understanding of the genetic basis for tooth development and eruption disorders.
Provides insights into molecular pathways that could be targeted for therapeutic interventions.
Contributes to the broader field of craniofacial development and regenerative medicine.