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Published on: February 22, 2019
ZBTB1 is a determinant of lymphoid development
Owen M Siggs1, Xiaohong Li, Yu Xia
1Department of Genetics, The Scripps Research Institute, La Jolla, CA 92037, USA.
The Journal of Experimental Medicine
|December 28, 2011
Summary
Researchers identified a mutation in the Zbtb1 gene causing T cell deficiency in mice. This finding highlights ZBTB1
Area of Science:
- Immunology
- Developmental Biology
- Genetics
Background:
- T cell development is crucial for adaptive immunity.
- Defects in lymphopoiesis can lead to immunodeficiency.
Purpose of the Study:
- To identify the genetic cause of a chemically induced T cell deficiency in mice.
- To elucidate the role of ZBTB1 in T cell development and lymphopoiesis.
Main Methods:
- Chemically induced mouse mutation model.
- Positional cloning and genetic analysis.
- Retroviral transduction and somatic reversion studies.
Main Results:
- A mutation in Zbtb1 (zinc finger and BTB domain containing 1) was identified as the cause of T cell deficiency.
- Zbtb1 mutation resulted in complete, cell-intrinsic T cell deficiency.
- Other lymphoid lineages were also impaired, especially under competitive conditions.
Conclusions:
- ZBTB1 is essential for T cell development.
- ZBTB1 plays a critical role in lymphopoiesis.
- ZBTB1 likely functions as a transcriptional regulator in immune cell development.
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