Does the Hounsfield unit value determined by computed tomography predict the outcome of percutaneous nephrolithotomy?
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Updated: May 26, 2026

In Vivo, Percutaneous, Needle Based, Optical Coherence Tomography of Renal Masses
Published on: March 30, 2015
Adnan Gücük1, Uğur Uyetürk, Ufuk Oztürk
1Department of Urology, Abant Izzet Baysal University Faculty of Medicine, Bolu, Turkey. gucukadnan@hotmail.com
Insights
Hounsfield unit (HU) values, stone size, and opacity independently predict percutaneous nephrolithotomy (PCNL) success. Higher HU values correlate with better PCNL outcomes, aiding treatment selection for kidney stones.
Area of Science:
- Nephrology
- Urology
- Radiology
Background:
- Percutaneous nephrolithotomy (PCNL) is a common procedure for kidney stone removal.
- Predicting PCNL outcomes is crucial for patient management and treatment planning.
Purpose of the Study:
- To evaluate if Hounsfield unit (HU) values from unenhanced CT scans can predict the outcome of PCNL.
- To identify key parameters influencing PCNL success rates.
Main Methods:
- Retrospective analysis of 179 patients who underwent PCNL.
- Data collected included patient demographics, stone characteristics (size, HU value, opacity, location), and complications.
- Logistic regression and receiver operating characteristic (ROC) analysis were used to determine predictors of failure.
Main Results:
- Stone size, opacity, and HU values were independent predictors of PCNL failure (P<0.05).
- A HU cutoff of 677.5 was identified; lower HU values increased failure risk (OR 2.65).
- Staghorn location (OR 5.68), larger stone size (≥485 mm², OR 1.9), and non-opaque stones (OR 6.04) also predicted failure.
Conclusions:
- HU values, alongside stone size and location, are significant predictors of PCNL outcomes.
- PCNL is more effective for stones with higher HU values.
- HU values can assist in selecting the optimal treatment modality for renal stones.
Purpose:
We aimed to evaluate whether the Hounsfield unit (HU) value predicts outcome in percutaneous nephrolithotomy (PCNL).
Patients And Methods:
One hundred and seventy-nine patients who had undergone PCNL in our clinics in the last 4 years were included. Demographic and clinical data of the patients and complications, if any, were recorded. The mean age of the patients was 45.3 ± 14.3 years (range 5-82 y), and 111 of them were males (62%). The mean stone size and HU values were found to be 693.1 ± 628.0 (95-4200) mm(2) and 706.3 ± 245.0 (214-1325), respectively.
Results:
In logistic regression analysis, the size of the stone, the opacity of the stone, and the HU values were found to be independent predictors of the failure of the procedure (P<0.05). A cutoff value of 677.5 was used for the HU in the receiver operating characteristics analysis. Having a HU value under the cutoff value increased the likelihood of procedure failure by 2.65 times, whereas stones residing in the staghorn localization increased failure by 5.68. It was also observed that if the stone's size was 485 mm(2) or more, the chance of failure increased by 1.9, whereas when the stone was nonopaque, failure increased by 6.04 times (P<0.05). There was a positive correlation between hematocrit decrease and a decrease in HU values (P<0.05), but no correlation was observed between the HU values and duration of surgery or fluoroscopy (P>0.05).
Conclusion:
In addition to the size and location of the stones, the HU value determined in the unenhanced CT scan may be one of the parameters affecting PCNL outcomes. PCNL is a more efficient method in stones with higher HU values. Therefore, the HU values may be a useful tool for the selection of the treatment modality in patients with renal stones.
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